2.2.3 Clinical Case 1 - Bartter's Syndrome Flashcards
E. B and C
What are four symptoms commonly identified in Bartter’s syndrome?
muscle weakness, polyuria, enuresis (bed wetting), polydipsia
D. Tubular function is abnormal due to increased excretion rates for both Na and K
C. Decreased K-conductance prolongs RT-interval and slows phase 3 depolarization to flatten T-wave
A. Hypokalemia
D. Kidney handling is abnormal for both sodium and potassium
D. All of the Above
Which diuretic acts to block/occupy the receptor of aldosterone?
Spironolactone
E. B and C
What three factors can aid in a diagnosis of Bartter’s Syndrome?
Renal K wasting
Metabolic alkalosis
Increased renin and aldosterone
What is a treatment method to minimize or eliminate the muscle weakness associated with Bartter’s syndrome?
K+ supplementation
E. A and B
What might you expect regarding lab values if a patient is suffering from bartter’s syndrome?
Decreased levels on Na, Cl, K, and HCO3
E. B and C
Based on the following values, what is your assessment of the glomerular function in this patient?
GFR is near normal
What are 4 treatment approaches for a patient suffering from Bartter’s syndrome?
K supplements and liberal salt intake to avoid electrolyte imbalances
Aldosterone antagonists and the diuretic spironolactone
ACE inhibitors to counteract the effects of ANG II and aldosterone
Nonsteriodal anti-inflammatory drugs (NSAIDs) to decrease prostaglandin excretion
E. B and C
D. Resorption of potassium is less than normal
What is causing the alkalosis in this patient?
Increased H excretion stimulated by aldosterone in the distal and collecting tubule
