2.1.1 Glomerular Disorders Nephritic and Nephrotic Syndromes II Flashcards
What systemic disease can lead to GBM thickening with nodular glomerulosclerosis (Kimmelstiel-Wilson nodules)?
Diabetes
Give three examples of systemic diseases that can lead to nephrotic syndrome?
Diabetes, amyloidosis, lupus
If you don’t know the answer, blame Miles or Joey.
Post-infectious glomerulonephritis (post-streptococcal GN)
Subepithelial electron dense “humps”
Know it, bro?
Mutation in COL4A5
Alport Syndrome
Name this dz: Most common in children, responsive to steriods, causes foot process effacement/fusion that can be seen on EM
Minimal change dz
You can do it, doc
Diabetic nephropathy
Kimmelstiel-Wilson nodule (nodule glomerulosclerosis)
What are the most common primary glomerular dz presenting with nephrotic syndrome in adults?
FSGS and membranous glomerulopathy
What is the most common primary glomerular dz presenting with nephrotic syndrome in children?
Minimal change dz
This could be your daughter. You better come up with the right answer
IF = negative; EM = foot process effacement
Minimal change dz
Steriods
What systemic disease has this pattern of deposition?
SLE - leading to membranous nephropathy
What are the three etiologic classifications of FSGS?
Primary (idiopathic), secondary, non-specific segmental glomerular scarring
What are the four symptoms found in nephrotic syndrome?
Proteinuria (>3.5 gm/day), hypoalbuminemia, edema, hyperlipidemia
“I done caught amnesia.” Which greatest rapper of all-time said this in a song?
Auto-Ab to COL4A3
Goodpasture syndrome
It was Kevin Gates if you were wondering
What are the different causes of the two types of MPGN (Ig+ and Ig-)?
What the answer, champ?
Henoch-Schonlein Purpura
What morphological subtype of FSGS are we responsible for on STEP? It is related to HIV, drug, idiopathic; worse prognosis.
Collapsing glomerulopathy
Name this dz: Proteinuria/nephrotic syndrome; diffuse, global thickening of GBM; subepithelial IgG and C3 by IF, EM; in situ immune complex formation for primary
Membranous glomerulopathy
Need a little pick me up after those questions?
Here is a picture of Miles prior to getting into medical school. His life was definitely trending downwards…
What is the most type of amyloidosis worldwide? What disease with a mutation in pyrin is of this type?
AA
Familial Mediterranean Fever
Name this dz: More of a pattern of injury than it is one particular dz; lobular hypercelluarity; double contous or “tram tracks” IF = usually peripheral C3, and either Ig+ or Ig-; EM = subendothelial deposits (Ig+) or intramembranous dense deposits (Ig-)
Membranoproliferative glomerulonephritis
Got an answer, pal?
ANCA (anti-GBM assay)
Wegner’s (GPA)
Which systemic disease is characterized by peripheral neuropathy and can lead to abnormal protein with beta-pleated sheet structure forming fibril deposits in the glomeruli? It is often detected by congo red staining.
Amyloidosis
What is the answer, bud?
Lupus nephritis
“Full house” (IgG, IgM, IgA, C3, C1q)
Name this systemic disease that affects the glomeruli.
Diabetes
Let me be your lighthouse
FSGS
Name 5 diseases that primarily affect glomeruli and lead to nephrotic syndrome.
Membranous glomerulopathy
Minimal change disease
Focal segmental glomerulosclerosis (FSGS)
Membranoproliferative glomerulonephritis
Other proliferative glomerulonephritides
Just keep swimming -DORY
Post-infectious GN
subepithelial electron dense “humps”
What are some of the causes of secondary membranous GN?
Drug, infection, neoplasms, autoimmune
What are some of the major histologic features of HIVAN?
Globally collapsed glomeruli
severe tubular microcytic dilation
Numerous tubular reticular inclusions (TRIs)
You is smart
Name this dz: Focal, segmental sclerosis, foot process effacement that can been seen on EM, unresponsive to sterioids.
Focal segmental glomerulosclerosis (FSGS)
What is the most common type of amyloidosis in the US?
AL, which is Ig light chain, usually lambda
a/w myeloma
