1.5.2 Glomerular Disease Part 1 Flashcards
What is this an image of?

Normal glomerulus
What are the characteristics of Henoch-Schonlein purpura?
It is morphologically indistinguishable from IgAN
Presents with systemic vasculitis
What are the features of secondary IgA nephropathy?
Associated with GI disease - espcially cirrhosis
What is this an image of?

Mesangial matrix expansion
p-ANCA is associated with?
MPA and Churg-Strauss
What will an IF image show in goodpastures?
IgG depositions on the glomerular basement membrane
What are the whited out figures?


What are the EM findings associated with with post-infectious glomerulonephritis?
Subepithelial humps
What is this an image of?

Nodular mesangial expansion
What are the arrows pointing at?

Sub-epithelial humps associated with with post-infectious glomerulonephritis
What is this an image of?

Tubuloreticular inclusion
What is this an image of?

post-infectious glomerulonephritis
notice high levels of neutrophils
What are the characteristics of accelerated hypertensive kidney disease?

What are IF findings associated with with post-infectious glomerulonephritis?
C3 depositions
What is this an image of?

IF image of C3 deposition with with post-infectious glomerulonephritis
What is this an image of?

Diffuse Lupus Nephritis (Class IV)
What is this an image of?

Arterial wall destruction due to ANCA associated renal dz
What is this an image of?

Scarring/sclerosis of glomeruli
What is this an image of?

Focal Lupus Nephritis (Type 3)
What is this an image of?

Sclerosis/scarring - hyaline deposits
What is this an image of?

Mesangial proliferation associated with IgA nephropathy
What is this an image of?

Mesangial hypercellularity
What is this an image of?

Thin basement membrance dz
What is this an image of?

Endocapillary hypercellularity
What are double contours?
These are typically a result of endothelial/subendothelial injury. Endothelial cells make new basement membrane.
What is this an image of?

Extrinsic hypercellularity - crescents
What is this an image of?

Crescent shaping - goodpastures
What are the clinical features of primary IgA nephropathy?
Recurrent hematuria associated with simultaneous upper respiratory infection
What are the characteristics of ANCA-associated GN?

What are the characteristics of thin basement membrane syndrome?

What is this an image of?

GBM associatied with IgA nephropathy
What is this?

Glomerular anatomy
What is this an image of?

Capillary thrombi associated with accelerated hypertensive kidney disease
What is this an image of?

Alport syndrome
What are some causes of mesangial matrix expansion?
DM or HTN
Ig or Ig complex deposition
What is this an image?

Lupus Nephritis (Immune complex deposition)
What is this an image of?

IgA deposition associated with IgA nephropathy
What are the clinical features of nephritis?
Hematuria
Mild-moderate proteinuria
HTN
Active urine sediment
What is this an image of?

Glomerular capillary thrombosis
What are the characteristic pathological findings associated with SLE?

What does segmental vs global mean when describing a glomerulus?
Segmental - involving parts of a glomerulus
Global - involving the entire glomerulus
What is this an image of?

Crescent shaping associated with ANCA nephritis
c-ANCA is associated with?
Wegener’s
What are the key features of Goodpasture’s Disease?

What are these images of?

Active urine sedimentation associated with nephritis
What are the main clinical features of nephrotic syndrome?
Proteinuria
Hypoalbuminemia
Edema
Hyperlipidemia
What is this an image of?

Accelerated hypertensive kidney disease
What are the pathological characteristics of primary IgA nephropathy?
Mesangial expansion/cellular proliferation
IgA
What is this an image of?

Structured deposits - fibrillar
What are the clinical features of post-infectious streptococcal glomerulonephritis?
Hypocomplementemia
Post infection with Group A Strep
Delay in symptoms - 1 to 2 weeks
What these image of?


What is this an image of?

Onion skin appearance of accelerated hypertensive kidney disease
What is this an image of?

Double contours
What are the light microscopy findings with post-infectious glomerulonephritis?
PMNs
Crescents
What are the characteristics of hereditary nephritis (Alport syndrome)?

What are the pathologic characteristics of chronic hypertensive glomerulopathy?
