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Renal and Endocrine > 1.5.2 Glomerular Disease Part 1 > Flashcards

1.5.2 Glomerular Disease Part 1 Flashcards

1
Q

What is this an image of?

A

Normal glomerulus

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2
Q

What are the characteristics of Henoch-Schonlein purpura?

A

It is morphologically indistinguishable from IgAN

Presents with systemic vasculitis

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3
Q

What are the features of secondary IgA nephropathy?

A

Associated with GI disease - espcially cirrhosis

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4
Q

What is this an image of?

A

Mesangial matrix expansion

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5
Q

p-ANCA is associated with?

A

MPA and Churg-Strauss

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6
Q

What will an IF image show in goodpastures?

A

IgG depositions on the glomerular basement membrane

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7
Q

What are the whited out figures?

A
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8
Q

What are the EM findings associated with with post-infectious glomerulonephritis?

A

Subepithelial humps

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9
Q

What is this an image of?

A

Nodular mesangial expansion

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10
Q

What are the arrows pointing at?

A

Sub-epithelial humps associated with with post-infectious glomerulonephritis

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11
Q

What is this an image of?

A

Tubuloreticular inclusion

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12
Q

What is this an image of?

A

post-infectious glomerulonephritis

notice high levels of neutrophils

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13
Q

What are the characteristics of accelerated hypertensive kidney disease?

A
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14
Q

What are IF findings associated with with post-infectious glomerulonephritis?

A

C3 depositions

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15
Q

What is this an image of?

A

IF image of C3 deposition with with post-infectious glomerulonephritis

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16
Q

What is this an image of?

A

Diffuse Lupus Nephritis (Class IV)

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17
Q

What is this an image of?

A

Arterial wall destruction due to ANCA associated renal dz

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18
Q

What is this an image of?

A

Scarring/sclerosis of glomeruli

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19
Q

What is this an image of?

A

Focal Lupus Nephritis (Type 3)

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20
Q

What is this an image of?

A

Sclerosis/scarring - hyaline deposits

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21
Q

What is this an image of?

A

Mesangial proliferation associated with IgA nephropathy

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22
Q

What is this an image of?

A

Mesangial hypercellularity

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23
Q

What is this an image of?

A

Thin basement membrance dz

24
Q

What is this an image of?

A

Endocapillary hypercellularity

25
Q

What are double contours?

A

These are typically a result of endothelial/subendothelial injury. Endothelial cells make new basement membrane.

26
Q

What is this an image of?

A

Extrinsic hypercellularity - crescents

27
Q

What is this an image of?

A

Crescent shaping - goodpastures

28
Q

What are the clinical features of primary IgA nephropathy?

A

Recurrent hematuria associated with simultaneous upper respiratory infection

29
Q

What are the characteristics of ANCA-associated GN?

30
Q

What are the characteristics of thin basement membrane syndrome?

31
Q

What is this an image of?

A

GBM associatied with IgA nephropathy

32
Q

What is this?

A

Glomerular anatomy

33
Q

What is this an image of?

A

Capillary thrombi associated with accelerated hypertensive kidney disease

34
Q

What is this an image of?

A

Alport syndrome

35
Q

What are some causes of mesangial matrix expansion?

A

DM or HTN

Ig or Ig complex deposition

36
Q

What is this an image?

A

Lupus Nephritis (Immune complex deposition)

38
Q

What is this an image of?

A

IgA deposition associated with IgA nephropathy

39
Q

What are the clinical features of nephritis?

A

Hematuria

Mild-moderate proteinuria

HTN

Active urine sediment

40
Q

What is this an image of?

A

Glomerular capillary thrombosis

41
Q

What are the characteristic pathological findings associated with SLE?

42
Q

What does segmental vs global mean when describing a glomerulus?

A

Segmental - involving parts of a glomerulus

Global - involving the entire glomerulus

43
Q

What is this an image of?

A

Crescent shaping associated with ANCA nephritis

44
Q

c-ANCA is associated with?

A

Wegener’s

45
Q

What are the key features of Goodpasture’s Disease?

46
Q

What are these images of?

A

Active urine sedimentation associated with nephritis

47
Q

What are the main clinical features of nephrotic syndrome?

A

Proteinuria

Hypoalbuminemia

Edema

Hyperlipidemia

48
Q

What is this an image of?

A

Accelerated hypertensive kidney disease

49
Q

What are the pathological characteristics of primary IgA nephropathy?

A

Mesangial expansion/cellular proliferation

IgA

50
Q

What is this an image of?

A

Structured deposits - fibrillar

51
Q

What are the clinical features of post-infectious streptococcal glomerulonephritis?

A

Hypocomplementemia

Post infection with Group A Strep

Delay in symptoms - 1 to 2 weeks

52
Q

What these image of?

53
Q

What is this an image of?

A

Onion skin appearance of accelerated hypertensive kidney disease

54
Q

What is this an image of?

A

Double contours

55
Q

What are the light microscopy findings with post-infectious glomerulonephritis?

A

PMNs

Crescents

56
Q

What are the characteristics of hereditary nephritis (Alport syndrome)?

57
Q

What are the pathologic characteristics of chronic hypertensive glomerulopathy?

Renal and Endocrine (46 decks)

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