1.1.3 Ureagenesis Nitrogen Excretion

Question 1

What are some of the sources for the carbon-nitrogen backbone in purines?

Answer 1

Question 2

What is the molecular basis of gout?

Answer 2

Over production of uric acid levels caused by:

1. Over production in the de novo pathway
2. Kidney damage resulting in reduced excretion
3. Mutations in the HGPRTase enzyme
4. Mutations in the PRPP synthetase enzyme resulting in the loss of allosteric or feedback inhibition

Question 3

How do human levels of Uric acid compare to other species, and why is this important?

Answer 3

Question 4

What is Lesch-Nyhan Syndrome?

Answer 4

Question 5

What is allopurinol and what is it used for?

Answer 5

Question 6

Describe the purine nucleotide salvage pathway.

Answer 6

Question 7

What are the major control steps in purine biosynthesis?

Answer 7

Question 8

What is the importance of IMP?

Answer 8

Precursor for AMP and GMP

Question 9

How do we treat gout?

Answer 9

Manage the inflammatory process

and

Reduce the levels of blood uric acid

Question 10

Describe the nucleotide cycle and anapleurotic action in mucle.

Answer 10

Question 11

What is the importance of myokinase/ adenylate kinase?

Answer 11

Question 12

What makes up the parts of nitrogen excretion?

Answer 12

Question 13

What is the role of Xanthine Oxidase?

Answer 13

Conversion of Xanthine to Uric Acid

Question 14

What conditions can lead to gout?

Answer 14

Remember the last two (most important)