1.4.2 Regulation of Extracellular Fluid and Electrolytes II Flashcards
How is calcium carried in the plasma?
Ionized (50%)
Protein-bound (40%)
Anion-bound (10%)
What are some of the transport mechanisms of Ca++ along the nephron?
What are some non-physiological regulators of K plasma levels?
Acid-base equilibrium (acidosis decreases K uptake)
Plasma osmolality (ECF hyperosmolality increases K exit)
Describe how K+ amount various along the nephron
What is the normal plasma level of chloride?
102 mEq/L
What the normal plasma level of Na?
135-145 mEq/L
What are the two locations of Mg++ reabsorption in the nephron and the channels utilized?
How is phosphate stored/carried in body?
Bone (90%)
Ionic and Bound (10%)
Where does most sodium reabsorption occur?
Proximal tubule (60-70%)
Ascending loop of Henle (25%)
Insulin, epinephrine, and aldosterone have what effect on cellular uptake of K?
Increase/activate uptake of K
Talk about vit D activation and some of its regulators
What is the Cl- transporter in the proximal tubule?
Paracellular
Name three regulators of K plasma levels?
Insulin, Epinephrine, Aldosterone
Acidosis cna lead to what conditon involving K?
Hyperkalemia
What are some factors that stimulate K+ secretion in the distal tubule?
Where is phosphate absorbed in the nephron? What are some of the channels involved?
Aldosterone regulates Na reabsorption in what part of the tubule system?
Distal and Collecting tubules
How is Mg++ stored/carried in the body?
Bone (55%)
ICF (44%)
Plasma (1%)
What is the main sodium channel in the proximal tubule? ascending loop of Henle?
Proximal tubule: Na-glucose, Na-AA, Na/H exchanger, Na channel
Ascending loop of Henle: NKCC channel
What is the normal plasma level of K?
4.5-5 mEq/L
What helps maintain high levels of K in all cells?
Na,K-ATPase
What are the regulators of Na transport along the nephron in the various tubules?
Where is K+ reabsorption/secretion variable depending upon dietary uptake?
Distal tubule
What are the important transporters K+ along the nephron?
Proximal: Paracellular
Loop of Henle: NKCC
Distal: K-channels
Want to see an image of J Batts before he got a gym membership?
Are you smart enough to summarize the transport of the various ions along the nephron epithelium?
Where does most K+ reabsorption occur?
Proximal tubule (60-70%)
Ascending loop of Henle (20%)
