[17] Oxidative Phosphorylation Flashcards

1
Q

What is Oxidative Phosphorylation?

A

The process that generates ATP from nutrients through redox reactions.

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2
Q

Where does Oxidative Phosphorylation occur?

A

In the mitochondria.

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3
Q

What are the two key components of Oxidative Phosphorylation?

A
  • Electron Transport Chain
  • ATP synthase
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4
Q

What is the role of NADH and FADH2 in Oxidative Phosphorylation?

A

They donate electrons to the Electron Transport Chain.

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5
Q

What is the Electron Transport Chain?

A

A series of proteins in the inner mitochondrial membrane that transfers electrons from NADH and FADH2 to oxygen.

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6
Q

What is ATP synthase?

A

An enzyme that creates ATP from ADP and inorganic phosphate.

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7
Q

How does the Electron Transport Chain create a proton gradient?

A

By pumping protons from the mitochondrial matrix to the intermembrane space.

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8
Q

What does the proton gradient do?

A

Powers ATP synthase to make ATP.

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9
Q

What is the final electron acceptor in the Electron Transport Chain?

A

Oxygen.

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10
Q

What is chemiosmosis?

A

The movement of ions across a selectively permeable membrane, down their electrochemical gradient.

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11
Q

What role does chemiosmosis play in Oxidative Phosphorylation?

A

It drives the phosphorylation of ADP to ATP.

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12
Q

How is water formed in Oxidative Phosphorylation?

A

By the reduction of oxygen at the end of the Electron Transport Chain.

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13
Q

What role does the inner mitochondrial membrane play in Oxidative Phosphorylation?

A

It holds the Electron Transport Chain and ATP synthase.

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14
Q

What is the P/O ratio?

A

The amount of ATP synthesized per oxygen atom reduced (typically around 2.5 for NADH and 1.5 for FADH2).

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15
Q

What is the role of coenzyme Q in Oxidative Phosphorylation?

A

It transfers electrons within the Electron Transport Chain.

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16
Q

What is the role of cytochrome c in Oxidative Phosphorylation?

A

It transfers electrons within the Electron Transport Chain.

17
Q

How many ATP are produced in Oxidative Phosphorylation per glucose molecule?

A

About 28 ATP.

18
Q

What is the difference between substrate-level phosphorylation and Oxidative Phosphorylation?

A

Substrate-level phosphorylation makes ATP directly, while Oxidative Phosphorylation uses a proton gradient.

19
Q

Why is oxygen necessary for Oxidative Phosphorylation?

A

It acts as the final electron acceptor in the Electron Transport Chain.