17/2

Question 1

siderblastic anaemia

• what
• causes
• Ix

Answer 1

what
- red cells fail to completely form haem

causes - congenital deficiency of delta-aminolevulinate synthase-2 deficiency, myelodysplasia, alcohol, lead, anti-TB

Ix
- hypochromic normocytic anaemia, high ferritin, high transferrin sats, basophilic stippling of RBCs

Question 2

common cause of neutropenia in african or caribbean patients

Answer 2

benign ethnic neutropenia

Question 3

mx - sickle cell disease

Answer 3

hydroxyurea - increase HbF

pneumonococcal polysaccharide vaccine every 5 years

Question 4

haemarthrosis without trauma is a sign of what

Answer 4

haemophilia A (8) and haemophilia B (9)

Question 5

irradiated blood products are associated with___ reaction

Answer 5

transfusion-associated graft versus host disease

Question 6

CLL can transform to

Answer 6

lymphoma, rickter’s transformation

Question 7

complication of coeliac disease

Answer 7

hyposplenism causing howell-jolly bodies

Question 8

non-urgent - rbc are transfused over what time

Answer 8

90-120 mins

Question 9

acute chest syndrome presentation

Answer 9

chest pain
dyspnoea
cough
hypoxia
new pulmonary infiltates on CXR

Question 10

marker of neutropenic sepsis

Answer 10

> 38 degrees

Question 11

thiaizde diuretics

• examples
• MOA
• common SE

Answer 11

ex - bendroflumethiazide

MOA - inhibits sodium absorption at DCT by blocking NaCl symporter

SE - dehydration, post hypotension, hyponatraemia, hypokalaemia, hypercalcaemia, gout, impaired GT, impotence

Question 12

thiazide-like diuretics - examples

Answer 12

indapamide and chlortalidone

Question 13

axillary nn injury

Answer 13

pt has difficulty abducting their arm after a humeral neck fracture

Question 14

first line for lower back pain

Answer 14

NSAIDs

Question 15

TIa + anticoag/ bleeding disorder

Answer 15

CT head to exclude haemorrhage

Question 16

double duct sign seen in

Answer 16

pancreatic cancer

Question 17

PE - mx

Answer 17

admit
o2
fluids
analgesia
apixaban

Question 18

DDx - sudden onset pleuritic chest pain

Answer 18

pneumothorax
PE
MI