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Question 1

G6PD deficiency

• inheritance
• features
• drug triggers
• dx

Answer 1

inheritance - male (x linked recessive),. african and mediterranean
features - neonatal jaundice, intravasc haemolysis, gallstones, splenomegaly, heinz odies (bite and blister cells)
drug triggers - malaria prophylaxis, ciprofloxacin, sulph group
dx - measure of G6PD activity

Question 2

haemolysis spherocytosis

• inheritance
• features
• dx

Answer 2

inheritance - male and female, auto dom, north european
features - neonatal jaundice, chronic, gallstones, splenomegaly, spherocytes
Dx - EMA binding

Question 3

sickle cell

• aplastic vs sequestration crisis
• fbc presentation

Answer 3

aplastic - reduced reticulocytes
sequestration - increased reticulocytes
fbc - normocytic anaemia and raised reticulocytes

Question 4

aplastic anamiea

• define
• features
• causes

Answer 4

define- pancytopaenia and hypoplastic bone marrow, peak 30Y
features - normocytic anaemia, leukopenia, lymphocytes spared, thrombocytopaenia, low reticulocytes
causes - idiopathic, congenital, drugs (cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold), toxins (benzene), infections (parvovirus, hepatitis), radiation

Question 5

mx of polycythaemia ruba vera

Answer 5

aspirin - decrease thrombus risk
venesection - keep hb normal
chemo - hydroxyurea (IN risk of secondary leukaemia), phosphorus-32 therapy

Question 6

APLS - pregnancy mx

Answer 6

aspirin + LMWH

Question 7

blood productmost likely to contain gram positive cocci

Answer 7

platelets

Question 8

VWF affects which clotting factor

Answer 8

transports factor VIII

Question 9

hodgkin’s lymphoma - poor prog

Answer 9

b symptoms - night sweats, wt loss, fever >38
disseminated
>60yrs

Question 10

unresolving c.diff - mx

Answer 10

fidaxomicin