Zinc Phosphide

Question 1

What has similar effects as Zn Phosphide?

Answer 1

Aluminum, Magnesium and Phosphide

Question 2

Under what conditions does Zn Phosphide liberate phosphine gas?

Answer 2

Acidic conditions

Question 3

T/F: Zn phosphide is water soluble?

Answer 3

FALSE

Insoluble in water

Question 4

What is acute toxicity of Zn Phosphide due to?

Answer 4

Phosphine gas

Question 5

What body conditions enhance toxicity?

Answer 5

Gastric acid

Question 6

What is chronic toxicity due to?

Answer 6

Zn phosphide and phosphine gas

Question 7

What does gastric acid do to Zn phosphide?

Answer 7

Hydrolysis of Zn Phosphide to phosphine gas

Question 8

What is a possible theory on the MOA of Zn phosphide?

Answer 8

inhibit oxidative phosphorylation and cellular energy production resulting in cell death

Question 9

What are major tissues that are affected?

Answer 9

Brain, heart, kidney, liver and lung

Question 10

T/F: there is rapid onset of CS post exposure?

Answer 10

TRUE

Question 11

What is death usually caused by in these patients?

Answer 11

Tissue anoxia

Question 12

How early can death be seen in these patients?

Answer 12

3-48 hrs.

Question 13

What are some CNS signs seen?

Answer 13

“Mad dog running”, yelping and convulsions

Question 14

What odor does this toxicant have?

Answer 14

Dead fish (acetylene) in stomach contents

Question 15

What are some laboratory changes that will be observed?

Answer 15

Metabolic acidosis, dehydration and hypocalcemia

Question 16

What can be done to “autodecontaminate” the patient?

Answer 16

Roll down the windows enroute