Fungicides (PCP) Flashcards
What is the source in PCP toxicosis?
ingestion- licking would treated with PCP, or contaminated water
inhalation- from treated walls in sheds and barns (even
if it was applied months or years before)
T/f: Volatile and can give off toxic vapors in toxic concentration especially
in high low temperature
False: vapors are more of a concern in HIGH temperature- think “Cow got stuck in a hot barn that was just treated with PCP- so STINKY in there”
what are some factors that decrease toxicity of PCP?
Cold temperature, antithyroid drugs and presence of body fat
-this is the only time is pays off to be fat!
how is PCP metabolized an excreted?
Metabolized by conjugation to glucuronic acid
– Glucuronides are excreted in urine
MOA of PCP?
uncouples oxidative phosphorylation and blocks or decreases ATP & increase your oxygen demand
-PCP decreases your energy!
if PCP decreases ATP and increases demand for O2 what can you expect to see systemically?)
Overheating, metabolic acidosis and dehydration
What is a pathoneumonic lesion noted in PCP tox?
Hyperkeratosis of the skin and villous like hyperplasia of urinary bladder mucosa in chronic cases
What are the lab specimens for Dx in a LIVe animal?
dead?
live- blood and urine
dead- liver and kidney
what do you give for tx of systemic acidosis resulting from PCP?
sodium bicarb!!
this is true for any toxicant that results in systemic acidosis
T/F: to treat we need to increase metabolism of the drug by raising the temperature pf the patient.
false- raising the temperature would increase the metabolism but we do not want to do this to treat- increases in temp would make PCP more toxic
we would want to cool the patient down to treat the overheating!
T/F: If the animal survives for 24 hours, chances for complete recovery are fair
true
A clinical sign of PCP toxicosis is DARK blood. What is this from?
oxygen deprivation
Which ones of these is NOT TRUE for PCP
– Rapid rigor mortis
– Local irritation of the skin and mucous membranes
– brain congestion and edema
– Degenerative changes in liver and kidney
brain congestion and edema does not occur in PCP toxicosis
the congestion and edema is PULMONARY!
T/F it doesn’t mater if it is acute or chronic FEVER is always present
trueee
PCP is a overheating/fever/hyperthermia toxicant! –> looks like a heat stroke!
