Phenoxy Derivatives of Fatty Acids (2,4-D)

Question 1

Is this a strong or weak acid?

Answer 1

Weak acid

Question 2

What is 2,4-D?

Answer 2

Herbicide

Question 3

2,4-D alters the metabolism of plants, what effect does this have on the body?

Answer 3

Increases toxicity by increasing accumulation of nitrate/cyanide

Question 4

T/F: 2,4-D is not degraded by rumen microflora and cannot alter the microflora?

Answer 4

TRUE

Question 5

What species is the most sensitive?

Answer 5

Dogs

Question 6

If the LD50 is 100 mg/kg- what level of toxicity is this herbicide?

Answer 6

Moderately toxic

Question 7

Where is this herbicide readily/poorly absorbed?

Answer 7

Readily: GI
Poor: Skin

Question 8

What is the main method of metabolization?

Answer 8

Hydrolysis

Question 9

What are the chemical properties of this herbicide making it excreted unchanged in urine?

Answer 9

Polar, water soluble and ionized

Question 10

What pH do you want your urine to be in order to enhance renal excretion?

Answer 10

Alkalitic urine

Question 11

What is the MOA of 2,4-D?

Answer 11

Uncouple oxidative phosphorylation and depress ribonuclease synthesis

Question 12

What are the main systems affected?

Answer 12

GI and NM

Question 13

What are some CS seen in ruminants?

Answer 13

Rumen atony, bloat, ulcers in buccal mucosa (acute)

Question 14

What are some CS seen in dogs?

Answer 14

Weakness of posterior muscles and opisthotonos

Question 15

What are some chemical parameters that will be elevated?

Answer 15

ALP, LDH and CK