Bromethalin Rodenticide

Question 1

T/F: Vitamin K is used as an antidote for bromethalin?

Answer 1

FALSE- this is a coagulative rodenticide

Question 2

What are the two sources of poisoning?

Answer 2

Ingestion and secondary toxicosis

Question 3

Which species is most susceptible, sensitive and resistant?

Answer 3

Susceptible: dogs
Sensitive: cats
Resistant: guinea pigs

Question 4

Small amounts of bromethalin are excreted in urine, based off of this information is this toxicant water or lipid soluble?

Answer 4

Lipid soluble- readily absorbed in the body means that little amounts will be excreted in the urine

Question 5

Where are the highest concentrations of bromethling found in the body?

Answer 5

Brain and fat

Question 6

Cerebral/spinal edema and increased cerebrospinal fluid pressure are a result of what?

Answer 6

Lack of adequate ATP means that the Na/K pump can’t work efficiently causing buildup of pressure and fluid

Question 7

What syndrome is acute toxicosis associated with?

Answer 7

Convulsant syndrome (4-36 hrs.): hindlimb weakness and ataxia

Question 8

What syndrome is chronic toxicosis associated with?

Answer 8

Paralytic syndrome (2-3 days): depression, tremors, hindlimb paralysis, loss of deep pain, decreased CP

Question 9

What species always develops the paralytic syndrome regardless of dose?

Answer 9

Cats

Question 10

What can be used to help decrease the cerebral edema and brain swelling?

Answer 10

Mannitol for cerebral edema

Dexmethasone for brain swelling