Fluoride Toxicosis Flashcards
What are the two types of fluorides still used and what are they used as?
Sodium fluoaluminate (plant insecticide) Hydrofluoric acid (industrial toxicant)
What part of fluoride forages contain high amounts of fluoride?
Herbaceous parts (NOT SEEDS)
Fluoride has a strong affinity for what?
Ca, Al and Fe
T/F: Chronic fluoride toxicosis is most common.
TRUE
T/F: Calcium fluoride is more toxic than soluble sodium fluoride
FALSE- opposite
Which age of animals are more sensitive?
YOUNG- still developing bones and teeth
Soluble fluorides are readily absorbed where?
GI tract
Where is fluoride stored?
Bones and teeth
Where is the major route of excretion?
Urine
What does chronic toxicosis typically cause?
alteration/delay of teeth mineralization and production of abnormal bone
What are CS seen with chronic toxicosis?
Lameness, exostoses, spontaneous fractures (osteoporosis), teeth have mottling and patchy loss of dentine, brown color around teeth, anorexia, emaciation, rough hair coat and decreased milk production
What are the histo changes?
Uneven mineralization, excessive osteoid tissue, cortical thickening, periosteal hyperostosis
What is the best specimen for chemical analysis?
Bone
At what ppm is considered significant?
> 1500 ppm
T/F: Elevated urine levels confirm recent exposure
TRUE
