Common Household Products

Question 1

Which household toxicant has high toxicity and is considered to be an endocrine disruptor due to the estrogenic activities?

Answer 1

Phenolic compounds

Question 2

Which species are most sensitive to phenolic compounds?

Answer 2

Cats

Question 3

How are phenolic compounds metabolized?

Answer 3

In the liver by conjugation to glucuronic acid- this is why cats are most sensitive because they lack these enzymes

Question 4

How do phenolic compounds harm your body?

Answer 4

Direct irritation causing coagulative necrosis (hepatotoxic, nephrotoxic and neurotoxic)

Question 5

What are some CS from phenolic compounds?

Answer 5

CNS signs, coagulative necrosis, painful white plaques, corneal damage

Question 6

What can be used for phenolic compound detoxification?

Answer 6

milk, egg whites or water

Question 7

Rank the detergents from most to least toxic. (Nonionic, anionic, cationic)

Answer 7

Cationic > Anionic > Nonionic

Question 8

What is the MOA of detergents?

Answer 8

Direct irritation of the skin/MM

Question 9

Ingestion of detergents causes what CS?

Answer 9

Nausea, vomiting, diarrhea and colic

Question 10

What are common uses of bleach products?

Answer 10

Household bleach (Na hypochlorite), non chlorine bleach (Na peroxide, Na perborate and enzymatic detergents)

Question 11

What is the MOA of bleach?

Answer 11

Combined with acid/ammonia solutions, release of Cl or Cl gas and hypochlourous acid