Fluoracetate (Compound 1080)

Question 1

What is fluoracetate used for?

Answer 1

Livestock protection collars

Question 2

What are the properties of 1080?

Answer 2

Odorless, water soluble and insoluble in most organic solvents

Question 3

Which species is most sensitive and which is most resistant?

Answer 3

Sensitive: dogs
Resistant: birds

Question 4

What is compound 1080 metabolized into?

Answer 4

Monofluoracetic acid by hydrolysis

Question 5

What does compound 1080 do once inside the cell?

Answer 5

Slowing of citric acid cycle and decrease cellular respiration/energy

Question 6

What systems are most affected?

Answer 6

Brain and heart

Question 7

What CS do dogs exhibit?

Answer 7

CNS stimulation and GI irritation

Death within 2-12 hrs.

Question 8

What CS do livestock exhibit?

Answer 8

Signs of heart failure- cardiac arrhythmias are main sign

Question 9

What CS are seen in cats/swine?

Answer 9

CNS/cardiac signs

Cats are VOCAL

Question 10

What bodily fluids should be evaluated?

Answer 10

Gastric contents and vomitus