X Foundations - Chpt 23 - Med Amin Flashcards
Who can prescribe Rx
Nurse Practitioner, PA’s
purpose of USP
US Pharmacopeia
program for standardization
purpose of NF
National Formulary
FDA tests all new drugs. 10 yrs min testing
.
How many years is proprietary for formulas
5yrs
Schedule 1
Highest potential for abuse. NO MEDICAL USE ACCEPTED
Schedule 2
Controlled Substance
Schedule 3
High potential for abuse
Schedule 4
Less potential for abuse
Types of Names for drugs
Brand Name
Generic Name
Checmical Name
Drug Action
Drugs ability to combine w cellular receptor. Local or systemic effect.
Pharmacology
study of drug’s effect on living organisms
Half Life
time taken to eliminate half the blood concentration of original drug dose. How well does the liver break down drug.
Heparin HL - 2hrs
Doctors create drug Rx based on
HL
Routes of entry - Speed
IV, SL, IM, PO, topical
Onset of Action
time for body to respond to drug
Peak plasma level
highest concentration of single drug dose before elimination rate equals rate of absorbtion
Plateau
when blood concentration level is maintained
Loading dose
extra high dose given at start of medication therapy.
drugs classiffied by
- Body system with which they interact
- Drugs approved therapeutic use
Routes
- Oral (SL, Buccal)
- Parenteral - other than GUT (injection, subQ, IM, IV)
- Topical
- Respiratory/Inhalation
Pharmacokinetics
How drugs move through body
- ABSORBTION (intest, rectal, SL)
- DISTRIBUTION (from blood to tissue, fluid) *
- METABOLISM (processed by body, Liver/kidney)
- EXCRETION (meds w be in glomerular filtrate, kidneys)
(*worry about distro if person protein starved and drug needs to bind to protein molecules or if patient has low cardiac rate)
If patient has problems with liver or kidney, they will have problems with what Pharmokinetic function?
Metabolism and Excretion
Polypharmacy
taking multiple pills
Drug Interaction
effect one drug has on another.
Pharmacodynamics
why are we getting the drug?kill bacteria, softening stool, lower bp?
Side effect
non therapeutic effect of drug, mild and predicatble (i.e. Benadryl causes sleepiness)
Adverse reaction
bad reaction
Drug Tolerance
body accustomed to drug and require larger dose for efficacy
Toxic Effect
body cannot metabolize drug, accumulates in body
Idiosyncratic reaction
very unpredictable reaction. unexpected response
- Over response (reacty violently to normal dose)
- under response (1g morphine, still fee pain)
- atypical response (opposite effect, awake for days when taking sleeping pill)
Factors affecting drug action
- genetics
- age
- height (no Rx without height/weight)
- weight
- physical condition (muscle/fate)
- mental condition
Pharmacokinteics
Absorption
Distribution
Metabolism
Excretion
DAW
dispense as written. (don’t substitute with generic)
MAR
Medication Admin Record
7 Rights
right client right drug right dose right route right time right documentation right to deny or refuse
Right TIME rules
have 1 hour on either side of scheduled medication time.
non compliant
when clients don’t take meds consitently
NEVER administer meds prepared by another nurse
never
NEVER leave meds by clients bedside to administer on their own
never
Pharmacology
study of drugs and their action on the living body
Pharmaceutical Phase
until given to patient - The making of the drug until absorption of the durg takes place in patient’s body
Pharmacokinetic Phase
movement of drugs’s active ingredient from body fluids into entire system to site where intended action of drug takes place.
Pharmacodynamic Phase
interaction of drug’s active ingredient with intended body tissue.
Drug Dosage based on
Half Life