Women Health Drugs Flashcards
The REV aromatase-inhib Anastrozole Use
ER Breast cancer
Synthetic P4, Levonorgestrel 4 Uses and Dosage
Anti-conception, Ovarian cysts, endomet cancer, breast disease
- Oral Dose Twice daily
In regards to Women Pharm
Exemestane MOA
Aromatase IRReversible inhbitor
In regards to Women Pharm
Tamoxifen 2 MOA
BREAST E2-R Blocker, Endomet and Bone E2-R Partial Agonist!
Tamoxifen Use
1st line ER Breast cancer tx and prevent
“Commy” Clomiphene 2 MOA
Partial E2 Agonist to inhibit ALL E2 in body, boosts GnRH by relieving neg feedback
Ulipristal Main use and Dosage
Morning After, Single dose within 5 days (120 hrs)
Contraceptive Ethinyl estradiol 3 serious sFx
Venous Thromboemolitic disease, MI, Stroke
In regards to Women Pharm
Ethinyl Estradiol MOA
Synth Estro Blocks FSH/LH Release
In regards to Women Pharm
Anastrozole MOA
Aromatase competitive inhibitor (cyp19A1)
What makes Raloxifene a special ER blocker?
Protects bone!
P4 Contraceptive, Levonorgestrel 3 sFx
Venous Thromboemolitic disease, MI, Stroke
Breast E2R blocker, Tamoxifen 3 sFx
Hot flashes, vag bleed, Endomet cancer (bc partial agonist)
Exemestane and Anastrozole (Aromatase blockers) 3 sFx less than Tamox, 2 sfX more than Tamox
Hot flash, Vag bleed, Endomet Cancer (less than Tamoxifen); Arthralgias, Vag Dryness (more than tamoxifen)
Levonorgestrel MOA
Synth progest blocks FSH/LH Release for contraception, thickens cervical mucus
Anastrozole and Exemestane are both ____ inhibitors
Aromatase
Commy Clomiphene Use
Anovulation or amenorrhea (trying to get preg)
The double ER-Blocker, Raloxifen 2 sFx
Hot Flashes, Leg cramps
Name the 2 aromatase inhibitors used to treat ER Breast Cancer
- Ana-Strozole
2. Exe-Mestane
When Levonrgestrel is used as Morning-After, what route and amount of dose is taken?
- Oral
- 0.75
Key difference of Levonorgestrel as Monring After vs Ulipristal morning after pill.
- Ulipristal is a single dose that BLOCKS endogenous progestrone
- Levo is a double dose that USES progesterone to thicken mucus and inhibit conception
In regards to Women Pharm
Finasteride MOA
Inhib 5a-Reductase for less DHT production
In regards to Women Pharm
Ulipristal MOA
Mixed progest recptor binder
Ethinyl estradiol 4 Uses
Contraceptive, Ovarian cysts, endomet cancer, breast disease
“Morning after” Ulipristal 3 sFx
Nausea, cramps, painful menstruation
In regards to Women Pharm
Finasteride 3 Use
BPH, hirsutism, baldness
Anastrozole and Exemestane (Aromatase blockers) 3 sFx less than Tamox, 2 sfX more than Tamox
Hot flash, Vag bleed, Endomet Cancer (less than Tamoxifen); Arthralgias, Vag Dryness (more than tamoxifen)
The 5AD-Blocker, Finasteride 2 sFx
Less libido, Erectile Dysfxn
The double ER-Blocker, Raloxifen 2 Uses
Osteoporosis, prevent breast cancer (SERM)
“Commy” Clomiphene 3 sFx
Hot flashes, Multiple preg, Nausea
Raloxifen 2 MOA, key distinguisher from Tamoxifen
Breast AND Endomet E2-R blocker, Bone E2-R Potent Agonist (SERM)
The IRR aromatase-inhib Exemestane Use
ER Breast Cancer
