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RWJ Endo Repro > Hypothalamic/Pituitary Drugs > Flashcards

Hypothalamic/Pituitary Drugs Flashcards

1
Q

Key “holy” IGF-1 Mimic Drug?

A

Mecasermin

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2
Q

What is the main LH Analog?

A

Lutropin Alpha

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3
Q

Tolvapatan Anti ADH main adverse effect

A

Hepatotoxicity

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4
Q

Lutropin is a _____ analog

A

LH

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5
Q

GnRH agonist with intermittent administration results in ____ LH/FSH

A

Increased

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6
Q

Pegvisomant antagonizes ______

A

GH Receptors

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7
Q

The GnRH agonists Leuprolide, Goserelin, and Nafarelin all treat ______ and _____ in women

A
  • Endometriosis

- Uterine Fibrods

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8
Q

Somewhat Counter-intuitively, To treat Central Precocious puberty you would adminster what class of drug?

A

GnRH Agonists

Such as Leuprolide or histrelin

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9
Q

Somatropin is a recombinant ______ drug

A

Growth Hormone

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10
Q

Ganirelix, Cetrorelix, Degarelix, and Elagolix are all _______

A

GnRH antagonists

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11
Q

Urofollitropin and follitropin a/b are both ______ analogs

A

FSH

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12
Q

Somatropin 3 Side effects in children

A
  1. Pseudomotor Cerebri
  2. Scoliosis
  3. Hyperglycemia
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13
Q

Bromocriptine and Cabergoline are both ____ agonists (“Kraber”)

A

Dopamine

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14
Q

Name the 2 SST analogs

A
  1. Octreotide

2. Lanreotide

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15
Q

Leuprolide, Goserelin, Histrelin, Nafarelin, and Triptorelin are all _______ that taste like Relish with hotdogs

A

GnRH agonists

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16
Q

To treat Endometriosis you would provide a______

A

GnRH Agonist

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17
Q

Somatropin 3 Side effects in Adults

A
  1. Bone/muscle aches
  2. Carpal Tunnel
  3. Edema
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18
Q

Why does Mecasermin cause hypoglycemia?

A

Because IGF-1 potentiates Insulin

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19
Q

2 adverse effects of the follitropins and lutropins, and choriogonadotropins?

A
  1. Ovarian Hyperstimulation Syndrome (OHSS)

2. Multiple Pregnancies

20
Q

The GnRH agonists Leuprolide, Goserelin, Histrelin, and Triptorelin all treat ____ in men with combo therapy of androgen receptor antagonists

A

Prostate Cancer

21
Q

Octreotide and Lanreotide are both ______ analogs

A

SST

22
Q

3 GnRH Agonist side effects in women?

A
  1. Hot flashes
  2. Decreased Libido/vag fryness
  3. Less bone density
    (as if Estrogen were inhib’d)
23
Q

3 Side effects of Oxytocin

A
  1. Fetal Distress
  2. Fluid Retention (ADH)
  3. Heart failure
24
Q

Oxytocin is adminstred for what 2 purposes

A
  1. Augment labor

2. Control uterine hemorrhage after delivery

25
Q

Key toxicity of Mecasermin?

A

Hypoglycemia

26
Q

Desmopressin treats ___ ____

A

Diabetes Insipidus

27
Q

“Holy” Mecasermin is a recombinant form of _____

A

IGF-1

28
Q

Oxytocin increases ______ contractions

A

Uterine

29
Q

Ganirelix and Cetrorelix are approved to block GnRH for Ovarin Hyperstim procedures, whereas Degarelix is used to treat ______

A

Prostate Cancer

30
Q

3 Side effects of SST analogs such as Octreotide and Lanreotide

A
  1. GI Problems
  2. Gallstones
  3. Bradycardia
31
Q

List the 5 GnRH agonists that you add to hotdogs

A
  1. Leuprolide
  2. Goserelin
  3. Histrelin
  4. Nafarelin
  5. Triptorelin
    (Relin=Relish)
32
Q

Out of the GnRH antagonists, _____ is the only Endometriosis treatment

A

Elagolix

Both start with E

33
Q

Desmopressin Acetate function

A

ADH agonist

34
Q

Degarelix blocks GnRH to fight prostate cancer, but Ganirelix/Cetrorelix are used for ____

A

Ovarian Stim procedures

35
Q

GnRH agonist with prolonged continuous administration results in _____ LH/FSH

A

Decreased

36
Q

Name the 4 Dubstep GnRH antagonsits

A
  1. Ganirelix
  2. Cetrorelix
  3. Degarelix
  4. Elagolix
37
Q

What is the main GH Receptor Antagonist?

A

Pegvisomant?

38
Q

Choriogonadotropin is a ____ analog that stimulates ____ receptors

A
  • hCG

- LH

39
Q

Conivaptan and Tolvaptan are both ______

A

ADH antagoinsts

40
Q

3 Genetic disorders that are treated by Somatropin

A
  1. Prader-Willi
    - Turner
    - Noonan
41
Q

If someone doesn’t respond to GH, then recombinant _____ can be used instead to more directly treat the problem.

A

Mecasermin

42
Q

If the SST analogs, Octreotide and Lanreotide, then the GH receptor antagonists _____ can be used

A

Pegvisomant

43
Q

Pegvisomant is actually a Poly-Ethyl-Glyco Mutated version of _____ that ends up antagonizing it.

A

GH

44
Q

What class of drugs helps treat BOTH Endometriosis as well as Uterine Leiomyomatas?

A

GnRH Agonists

Leuprolide, Goserelin, Nafarelin

45
Q

Flutamide and Bicalutamide are both _____ receptor antagonists

A

Androgen

46
Q

Adminstration of GnRH blocker Elagolix?

A

Oral

47
Q

Key drug to treat diabetes insipidus that’s given INTRANASALLY?

A

Desmopressin

RWJ Endo Repro (26 decks)

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