Hypothalamic/Pituitary Drugs Flashcards
Key “holy” IGF-1 Mimic Drug?
Mecasermin
What is the main LH Analog?
Lutropin Alpha
Tolvapatan Anti ADH main adverse effect
Hepatotoxicity
Lutropin is a _____ analog
LH
GnRH agonist with intermittent administration results in ____ LH/FSH
Increased
Pegvisomant antagonizes ______
GH Receptors
The GnRH agonists Leuprolide, Goserelin, and Nafarelin all treat ______ and _____ in women
- Endometriosis
- Uterine Fibrods
Somewhat Counter-intuitively, To treat Central Precocious puberty you would adminster what class of drug?
GnRH Agonists
Such as Leuprolide or histrelin
Somatropin is a recombinant ______ drug
Growth Hormone
Ganirelix, Cetrorelix, Degarelix, and Elagolix are all _______
GnRH antagonists
Urofollitropin and follitropin a/b are both ______ analogs
FSH
Somatropin 3 Side effects in children
- Pseudomotor Cerebri
- Scoliosis
- Hyperglycemia
Bromocriptine and Cabergoline are both ____ agonists (“Kraber”)
Dopamine
Name the 2 SST analogs
- Octreotide
2. Lanreotide
Leuprolide, Goserelin, Histrelin, Nafarelin, and Triptorelin are all _______ that taste like Relish with hotdogs
GnRH agonists
To treat Endometriosis you would provide a______
GnRH Agonist
Somatropin 3 Side effects in Adults
- Bone/muscle aches
- Carpal Tunnel
- Edema
Why does Mecasermin cause hypoglycemia?
Because IGF-1 potentiates Insulin
2 adverse effects of the follitropins and lutropins, and choriogonadotropins?
- Ovarian Hyperstimulation Syndrome (OHSS)
2. Multiple Pregnancies
The GnRH agonists Leuprolide, Goserelin, Histrelin, and Triptorelin all treat ____ in men with combo therapy of androgen receptor antagonists
Prostate Cancer
Octreotide and Lanreotide are both ______ analogs
SST
3 GnRH Agonist side effects in women?
- Hot flashes
- Decreased Libido/vag fryness
- Less bone density
(as if Estrogen were inhib’d)
3 Side effects of Oxytocin
- Fetal Distress
- Fluid Retention (ADH)
- Heart failure
Oxytocin is adminstred for what 2 purposes
- Augment labor
2. Control uterine hemorrhage after delivery
Key toxicity of Mecasermin?
Hypoglycemia
Desmopressin treats ___ ____
Diabetes Insipidus
“Holy” Mecasermin is a recombinant form of _____
IGF-1
Oxytocin increases ______ contractions
Uterine
Ganirelix and Cetrorelix are approved to block GnRH for Ovarin Hyperstim procedures, whereas Degarelix is used to treat ______
Prostate Cancer
3 Side effects of SST analogs such as Octreotide and Lanreotide
- GI Problems
- Gallstones
- Bradycardia
List the 5 GnRH agonists that you add to hotdogs
- Leuprolide
- Goserelin
- Histrelin
- Nafarelin
- Triptorelin
(Relin=Relish)
Out of the GnRH antagonists, _____ is the only Endometriosis treatment
Elagolix
Both start with E
Desmopressin Acetate function
ADH agonist
Degarelix blocks GnRH to fight prostate cancer, but Ganirelix/Cetrorelix are used for ____
Ovarian Stim procedures
GnRH agonist with prolonged continuous administration results in _____ LH/FSH
Decreased
Name the 4 Dubstep GnRH antagonsits
- Ganirelix
- Cetrorelix
- Degarelix
- Elagolix
What is the main GH Receptor Antagonist?
Pegvisomant?
Choriogonadotropin is a ____ analog that stimulates ____ receptors
- hCG
- LH
Conivaptan and Tolvaptan are both ______
ADH antagoinsts
3 Genetic disorders that are treated by Somatropin
- Prader-Willi
- Turner
- Noonan
If someone doesn’t respond to GH, then recombinant _____ can be used instead to more directly treat the problem.
Mecasermin
If the SST analogs, Octreotide and Lanreotide, then the GH receptor antagonists _____ can be used
Pegvisomant
Pegvisomant is actually a Poly-Ethyl-Glyco Mutated version of _____ that ends up antagonizing it.
GH
What class of drugs helps treat BOTH Endometriosis as well as Uterine Leiomyomatas?
GnRH Agonists
Leuprolide, Goserelin, Nafarelin
Flutamide and Bicalutamide are both _____ receptor antagonists
Androgen
Adminstration of GnRH blocker Elagolix?
Oral
Key drug to treat diabetes insipidus that’s given INTRANASALLY?
Desmopressin