Hypothalamic/Pituitary Drugs

Question 1

Key “holy” IGF-1 Mimic Drug?

Answer 1

Mecasermin

Question 2

What is the main LH Analog?

Answer 2

Lutropin Alpha

Question 3

Tolvapatan Anti ADH main adverse effect

Answer 3

Hepatotoxicity

Question 4

Lutropin is a _____ analog

Answer 4

LH

Question 5

GnRH agonist with intermittent administration results in ____ LH/FSH

Answer 5

Increased

Question 6

Pegvisomant antagonizes ______

Answer 6

GH Receptors

Question 7

The GnRH agonists Leuprolide, Goserelin, and Nafarelin all treat ______ and _____ in women

Answer 7

• Endometriosis

- Uterine Fibrods

Question 8

Somewhat Counter-intuitively, To treat Central Precocious puberty you would adminster what class of drug?

Answer 8

GnRH Agonists

Such as Leuprolide or histrelin

Question 9

Somatropin is a recombinant ______ drug

Answer 9

Growth Hormone

Question 10

Ganirelix, Cetrorelix, Degarelix, and Elagolix are all _______

Answer 10

GnRH antagonists

Question 11

Urofollitropin and follitropin a/b are both ______ analogs

Answer 11

FSH

Question 12

Somatropin 3 Side effects in children

Answer 12

1. Pseudomotor Cerebri
2. Scoliosis
3. Hyperglycemia

Question 13

Bromocriptine and Cabergoline are both ____ agonists (“Kraber”)

Answer 13

Dopamine

Question 14

Name the 2 SST analogs

Answer 14

1. Octreotide

2. Lanreotide

Question 15

Leuprolide, Goserelin, Histrelin, Nafarelin, and Triptorelin are all _______ that taste like Relish with hotdogs

Answer 15

GnRH agonists

Question 16

To treat Endometriosis you would provide a______

Answer 16

GnRH Agonist

Question 17

Somatropin 3 Side effects in Adults

Answer 17

1. Bone/muscle aches
2. Carpal Tunnel
3. Edema

Question 18

Why does Mecasermin cause hypoglycemia?

Answer 18

Because IGF-1 potentiates Insulin

Question 19

2 adverse effects of the follitropins and lutropins, and choriogonadotropins?

Answer 19

1. Ovarian Hyperstimulation Syndrome (OHSS)

2. Multiple Pregnancies

Question 20

The GnRH agonists Leuprolide, Goserelin, Histrelin, and Triptorelin all treat ____ in men with combo therapy of androgen receptor antagonists

Answer 20

Prostate Cancer

Question 21

Octreotide and Lanreotide are both ______ analogs

Answer 21

SST

Question 22

3 GnRH Agonist side effects in women?

Answer 22

1. Hot flashes
2. Decreased Libido/vag fryness
3. Less bone density
   (as if Estrogen were inhib’d)

Question 23

3 Side effects of Oxytocin

Answer 23

1. Fetal Distress
2. Fluid Retention (ADH)
3. Heart failure

Question 24

Oxytocin is adminstred for what 2 purposes

Answer 24

1. Augment labor

2. Control uterine hemorrhage after delivery

Question 25

Key toxicity of Mecasermin?

Answer 25

Hypoglycemia

Question 26

Desmopressin treats ___ ____

Answer 26

Diabetes Insipidus

Question 27

"Holy" Mecasermin is a recombinant form of _____

Answer 27

IGF-1

Question 28

Oxytocin increases ______ contractions

Answer 28

Uterine

Question 29

Ganirelix and Cetrorelix are approved to block GnRH for Ovarin Hyperstim procedures, whereas Degarelix is used to treat ______

Answer 29

Prostate Cancer

Question 30

3 Side effects of SST analogs such as Octreotide and Lanreotide

Answer 30

1. GI Problems 2. Gallstones 3. Bradycardia

Question 31

List the 5 GnRH agonists that you add to hotdogs

Answer 31

1. Leuprolide 2. Goserelin 3. Histrelin 4. Nafarelin 5. Triptorelin (Relin=Relish)

Question 32

Out of the GnRH antagonists, _____ is the only Endometriosis treatment

Answer 32

Elagolix | Both start with E

Question 33

Desmopressin Acetate function

Answer 33

ADH agonist

Question 34

Degarelix blocks GnRH to fight prostate cancer, but Ganirelix/Cetrorelix are used for ____

Answer 34

Ovarian Stim procedures

Question 35

GnRH agonist with prolonged continuous administration results in _____ LH/FSH

Answer 35

Decreased

Question 36

Name the 4 Dubstep GnRH antagonsits

Answer 36

1. Ganirelix 2. Cetrorelix 3. Degarelix 4. Elagolix

Question 37

What is the main GH Receptor Antagonist?

Answer 37

Pegvisomant?

Question 38

Choriogonadotropin is a ____ analog that stimulates ____ receptors

Answer 38

- hCG | - LH

Question 39

Conivaptan and Tolvaptan are both ______

Answer 39

ADH antagoinsts

Question 40

3 Genetic disorders that are treated by Somatropin

Answer 40

1. Prader-Willi - Turner - Noonan

Question 41

If someone doesn't respond to GH, then recombinant _____ can be used instead to more directly treat the problem.

Answer 41

Mecasermin

Question 42

If the SST analogs, Octreotide and Lanreotide, then the GH receptor antagonists _____ can be used

Answer 42

Pegvisomant

Question 43

Pegvisomant is actually a Poly-Ethyl-Glyco Mutated version of _____ that ends up antagonizing it.

Answer 43

GH

Question 44

What class of drugs helps treat BOTH Endometriosis as well as Uterine Leiomyomatas?

Answer 44

GnRH Agonists | Leuprolide, Goserelin, Nafarelin

Question 45

Flutamide and Bicalutamide are both _____ receptor antagonists

Answer 45

Androgen

Question 46

Adminstration of GnRH blocker Elagolix?

Answer 46

Oral

Question 47

Key drug to treat diabetes insipidus that's given INTRANASALLY?

Answer 47

Desmopressin