Breast Malignancies Flashcards
2 Key Histo findings of the LOW Cancer Risk, Proliferative Lesion: Sclerosing Adenosis
- Lots of Fibrosis & Matrix
- Radial Scar Stroma
Fibroadenomas and Phylloides tumors affect the _____ of the breast
Stroma
What are 3 atypical presentations of breast cancer?
- Eczematous Skin
- Scaly Skin
- Red Inflamm
Atypical Breast Cancer from Paget’s results from Ductal infiltrate into the _______, whereas Inflamm Breast cancer has Ductal infiltrates into the _____
- Epidermis
- Lymph Nodes
Key histo finding of Fibroadneoma?
Compressed Gland
(Look like slit)
Intraductal papilloma, abscesses/mastitis, and paget’s disease all affect the ______ and _____ of the breast
- Lactiferous Duct
- Major Duct
Ddx for breast lump in 20-year-old
Acute Mastitis (Lactational or Nonlactational infection)
Key surface markers for breast cancer?
- Estrogen
- Progesterone
- Her-2/Neu
A phylloides tumor is similar to a fibroadenoma because it ALSO makes a stromal tumor, however, it is associated with chromosomal changes, and has high levels of ______ activity
Mitotic
What risk do Papillomas, sclerosing adenosis, Fibroadenomas, and a Phylloides tumor have towards cancer?
Low-Risk
Ddx for breast lump in 60-year-old
Cancer
The breast Acini, just like the prostate are _____ cells thick
2
BRCA1 and 2 are both ______ proteins
Anti-Tumor
Key clinical finding of the Proliferative Intraductal Papilloma of the breast?
BLOODY NIPPLE
Periductal Mastitis commonly occurs with people who _____
Smoke
Paget disease malignant cells fail to have a _____ stain
Cytokeratin
Key difference from Lobular vs Ductal carcinoma aside from the location?
Only DUCTAL is actually a true cancer
Invasive lobular Carcinoma has what key histo finding?
Indian File-Cell Arrangement
Acute mastitis, Periductal mastitis, Duct Ectasia all share what in common in regards to breast pathology?
Benign Breast Disease
Simple Cysts, Fibrosis, Apocrine Metaplasia, and Adenosis all share what in common in regards to breast pathology?
Non-Proliferative Breast Changes
Define Breast Adenosis and when it’s seen
- Increased acini per lobule
- Common with pregnancy
Describe Normal Breast Histology
Looks like a tree with wide stroma on the outside and neatly organized ducts
Fibroadenoma vs Cyst appearance on Imaging?
- Cyst is all black (anechoic)
- Fibro adenoma has grays
Ductal Carcinoma In situ has many micro-calcifications and what what key histo presentation?
Central Necrosis (Comedo)
Why does Paget’s Breast Disease present with Eczematous skin and swelling?
Epidermal Junction Disruption
2 Key clinical findings of Inflammatory Breast Cancer
- Orange Peel
- Redness
Papillomas, sclerosing adenosis, Fibroadenomas, and a Phylloides tumor all share what in common in regards to breast pathology?
Proliferative Breast Disease
Redness, induration, fever, chills in a young breast would make you think ______ whereas in a old breast you would think _____
- Mastitis (infection)
- Cancer
What risk do Non-proliferative Breast changes such as Simple Cysts, Fibrosis, Apocrine Metaplasia, and Adenosis have towards cancer?
None
