Endocrine Pathology

Question 1

Werner MEN-1 vs Sipply MEN-2A difference in Parathyroid

Answer 1

• MEN1= Adenoma
• MEN2= Hyperplasia

Question 2

Orphan Annie Thyroid cells with cleared nuclei filled from excess cytoplasm is pathognomonic for ____ _______

Answer 2

Papillary Carcinoma

Question 3

Type 1 Diabetes histologically shows more _____ whereas Type 2 shoes more ______

Answer 3

• Lymphocytes
• Amyloid

Question 4

Thyroid Medullary Carcinoma derives from ____ Cells

Answer 4

C-

(Parathyroid)

Question 5

In Follicular Adenoma the inside follicles differ from the outside follicles, what 2 Key histo characteristics should you also look for?

Answer 5

1. Continuous Capsule
2. Compressed Outer Follicles

Question 6

Werner syndrome is a _____ mutation, also known as _______ syndrome

Answer 6

• Menin
• MEN-1

Question 7

2 Key Histological Characteristic of Pituitary Adenomas

Answer 7

1. No Capsule
2. Large Nuclei near Capillaries

Question 8

Pheochromocytomas are neoplasms of endoderm derived _____ cells that secrete catecholamines and peptide hormones. Often are found in Organ of Zuckerkandl (aortic bifurc) and other places bilaterally

Answer 8

Chromaffin

Question 9

In a craniopharyngoma, considering its origin, look for ___ ____ epithelium

Answer 9

Stratified Squamous

Question 10

Solitary Thyroid nodules are usually found in the ____ . Hot nodules are more likely to be benign and the _____ must be examined!

Answer 10

• Colloid
• Capsule

Question 11

Look for _____ granules in Medullary Carcinoma

Answer 11

Calcitonin

Question 12

2 Key findings of Thyroid Follicular CARCINOMA

Answer 12

1. Invade Capsule
2. Invade Vessels

(No continuous outer capsule like in Adenoma)

Question 13

Key Histo Characteristic of Graves Disease

Answer 13

Sparse Colloid

Question 14

The Key Pathognmonic finding for Papillary Thyroid carcinoma are ____ _____

Answer 14

Orphan Annie Cells

Question 15

2 Histo Characteristic of Hashimoto’s Thyroidits

Answer 15

1. Lymphocyte Infiltration
2. Hurthe Cells (transformed Follicular cells)

Question 16

Sipple syndrome is from a mutation in _____ also known as ______ syndrome

Answer 16

• RET
• MEN-2A

Question 17

Subacute Granulomatous (De Quervain’s”) Thyroditis is usually caused by a _____, that usually causes transient hyperthyroidism, with _____ bands, and _____ cells

Answer 17

• Virus
• Fibrotic
• Giant

Question 18

_____ is the most common type of functioning adenoma for Endo

Answer 18

Prolactinoma