Lubitz Hypothal/Pituit Disorder

Question 1

When the pituitary gland gets bigger due to pregnancy and starts to infarct it is known as _____ Syndrome

Answer 1

Sheehan’s

Question 2

Prolactin is tonically inhibited by _____

Answer 2

Dopamine

Question 3

Bi-Temporal Hemi-Anopsia is associated with what tumor?

Answer 3

Pituitary

Question 4

Unlike most pituitary tumors, First-line treatment for prolactinoma is _____

Answer 4

NON-SURGERY

Question 5

Sheehan’s Syndrome is hypopituitarism after blood loss while giving birth due to hypertrophy of ____ that increased the pituitary’s size without extra blood.

Answer 5

Lactotrophs

Question 6

Primary Hypothyroidism results in the ______ of both TRH and PRL

Answer 6

Increase

Question 7

Why is IGF-1 Testing preferred over Growth Hormone testing?

Answer 7

GH fluctuates throughout the day

Question 8

Best way to diagnose HyperProlact?

Answer 8

• Direct, single test.

- rule out pregnancy and hypothyroidism

Question 9

What visual defect do pituitary tumors cause?

Answer 9

Bitemporal Hemianopsia (peripherals)

Question 10

Two notable endo dysfunctions in acromegaly, aside from heart and bone problems

Answer 10

1. Hypogonadism

2. Hyperglycemia

Question 11

The hormone _____ is tonically inhibited by dopamine

Answer 11

Prolactin

Question 12

Growth Hormone acts on the liver to synthesize ______

Answer 12

IGF-1

Question 13

Prolactinomas are associated with _______ syndrome, involving pituitary, parathyroid, and pancreas

Answer 13

MEN1

Question 14

The genetic disorder that results in anosmia, hypogonadism with low FSH and LH is known as _____ ____ and happens because GnRH neurons migrate improperly.

Answer 14

Kallman Syndrome

Question 15

Lubitz’s 3 Steps to Endocrine Pathology

Answer 15

1. Screen
2. Confirm
3. Localize

Question 16

What confirmatory test do you do for Excess GH vs Low GH? Consider what stimulates or inhibits GH release.

Answer 16

• For excess: Give Glucose

- For deficiency: Give insulin

Question 17

HyperProlact causes bone and other problems because it inhibits ________

Answer 17

GnRH

Question 18

Best way to diagnose Acromegaly is screening for _______

Answer 18

IGF-1

Question 19

Kallman syndrome 2 facts

Answer 19

1. Anosmia

2. Hypogonadism

Question 20

3 problems from Prolactin inhibiting GnRH

Answer 20

1. Weak Bone
2. Infertile
3. Amenorrhea

Question 21

While dopamine tonically inhibits prolactin, aside from oxytocin and Estrogens, what seemingly unrelated hormone will promote the secretion of Prl?

Answer 21

TRH