Ovarian Malignancies Flashcards
Of the Ovarian Germ Cell cancers, which is most likely to be benign?
Teratoma
In general, for ovarian cancer you want to look for a boosted ______ trans-membrane protein
CA-125
Gross appearance of Mucinous tumor?
JUMBO
“Jumo Ras Bois”
Key Histo finding for Ovarian Epithelial Serous cancer? (it is found in other cancers too)
Psammoma body
“Serious Psam”
2 Key Lab findings for Malignant Ovarian Dysgerminoma
- LDH Boost
- Alk Phos Boost
- (NO AFP, SOMETIMES HCG)
Serous, Mucinous, Transitional cell (also endometrioid and clear cell) are _____ _____ Ovarian Stroma cancers. (where are they?)
Surface Epithelium
In regards to Surface Ovarian Epithelial stroma cancers, what’s special about Cystic Serous’s behavior?
It can be either benign or malignant
Most Ovarian tumors are unilateral, which one is most likely to be bilateral?
Serous Epithelial Stroma
Call-Exner bodies are pathognomic for which ovarian cancer?
Granulosa
“Granny is lone wolf and loves coffee”
Ovarian Dysgerminoma looks just like make seminoma histologically, look for _______-looking cells without AFP!
Fried Egg
Ovarian “coffee” Granulosa cells pump out a lot of E2, but the key marker is _____
INHIBIN
“Granny is a lone wolf and loves coffee”
Sruma Ovarri and NMDA Neural are two subtypes of what kind of Ovarian Cancer?
Teratoma Germ-Cell
Benign vs malignant serous ovarian cancer; which is more likely to be bi-lateral?
Malignant
“bad guys love to hit both sides”
Brenner tumors are [benign or malig?] (_____) Transitional Cell (Surface Epithel) Ovarian tumors with what key Histo/Gross features?
- Benign
- Encapsulated
Random ovary trivia: What is a Krukenberg Tumor?
Gastric Cancer metastasizing to Ovary
In regards to Ovarian fibromas, what is Meig’s Syndrome Triad?
- Pelvic Mass
- Ascites
- R. Sided pleural effusion
Mucinous Ovarian Surface epithelium cancers are JUMBO bois with what key patho mutation?
RAS Mutation
“Jumbo Ras bois”
What two kinds of patient will be key findings for Ovarian Sex Cord Cancers?
- Precocious Children
- Bleedy Post-Menopasual Women
Key histo finding for Granulosa Ovarian cancer?
Call-Exner Bodies (Coffee Circles)
“Granny is lone wolf and loves coffee”
Name the 2 Ovarian Teratoma Germ Cell Cancer Sub-types
- Sruma (thyroid activating)
- NMDA Neural (psych probs)
Why are Ovarian fibromas the most unique Sex-Cord Cancer?
Hormonally inactive
Malignant Ovarian yolk sac Germline cancer create a lot of AFP, hit younger ppl, and present with what key histological finding?
Schiller Duval (Glomerulus-Like)
Teratomas, Dysgminoma, Yolk Sac, (and embryo carcinoma and chorio carcinoma), are all ______ ____ ovarian cancers
Germ-Cell
If you see boosted CA-125 transmembrane protein in a female, then you would suspect _____ cancer
Ovarian
3 Common symptoms of ovarian cancer
- Bloating/Satiety
- Nausea
- Painless
