Gynecologic Pathology Flashcards
Both have leukoplakia; differentiate Lichen Simplex Chronicus vs Lichen Sclerosus in regards to Chronicus (2 facts)
- Thick Epithelium & Hyperkeratosis
- No linkage to cancer
An obstructed vaginal Bartholin duct can be infected, commonly by what 2 pathogens?
- E. Coli
- N. gonorrhoeae
Lichen Sclerosus has what 3 Vaginal characteristics?
- Thin Epidermis
- A-cellular Dermal Fibrosis
- Smooth, white plaques (leukoplakia)
Koilocytosis, whereby there’s a nuclear contour and perinuclear cytoplasmic vacuolization, is HALLMARK for ____ infections
HPV
When diethylstilbestrol causes vaginal cancer it is usally ___ ___ ___
Clear Cell Adenocarcinoma
When HPV causes cancer, it is usually ______
Squamous Cell Carcinoma (SCC)
“The HPV won’t let me be, let me SCC”
Key Histo finding of Intra Epithel Adenocarcinoma known as Extramammary Page’ts Disease
PALE CYTOPLASM Mucin cells
3 Physical presentations of Vaginal Extramammary Paget Disease, which is considered to be an intraepithelial ADENOcarcinoma
- Well Demarcated, Raised Lesion
- Red, Eczematoid Background
- Pale, Multi-focal islands
90% of Vulva Carcinomas are squamous Cell. There are 2 types of Squam Cancer; 1 is linked to _____ and the other results in ____ squam Cell Carcinoma
- HPV 16
- Non-HPV Keratinizing
Out of the two Vulvar Squam Cell Carcinomas, ONLY the one linked to HPV shows precancerous changes in the epithelium termed ___ ___ ___ (___)
- Vulvar Intraepithelial Neoplasia (VIN)
While Vaginal Lichen sclerosus is benign, some women develop ____ ____ ___
HPV-Negative Squam.- Cell Carcinoma
Condylomata lata vs Condylomata acuminata
- Lata= Flat=Syphilis
- Acuminata=Elevated=HPV
Pathognomonic Histo feature of HPV infection?
Koilocytosis (wrinkled nuclear contour)
Vaginal Squamous Cell Carcinoma is associated with ____, whereas Clear Cell Adenocarcinoma is associated with _____
- HPV
- Diethylstilbestrol
In Extramammary Paget’s, the presence of ______ is useful to distinguish from Vullvar Melanoma!
Mucin
