Pediatric Growth Flashcards

1
Q

How do you distinguish Turner Syndrom Growth Chart (Pathological) from Familial/Constitutional (Non-Pathological)?

A

Turner’s stature is significantly shifted down and right

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2
Q

A short female patient should always be tested for _____ syndrome

A

Turner

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3
Q

Key Growth Chart difference between Hypothyroidism and Glucocorticoid Excess?

A
  • Hypothyroid weight is only slightly above average

- Gluco weight is significantly above average

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4
Q

Obese patient growth chart due to exogenous causes (food) will have an increase in weight with Height following which 2 possible patterns?

A

staying steady or accelerating further up

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5
Q

_____excess in McCune Albright Syndrome results in Mutli-organ G-protein activation, Cafe au lait macules, Polyostotic fibrous dysplasia and what other key physical finding?

A
  • GH

- Precocious Puberty

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6
Q

Key GH deficiency stature growth chart pattern

A

Slope looks like it will never rise

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7
Q

Klinefelter’s patients appear normal at birth, at childhood some behavioral problems/delays, but ALSO have scoliosis and Tall Stature due altered ____ ____

A

SHOX Gene

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8
Q

In regards to pathological short stature, GH deficiency, hypothyroidism, Cushing’s all have what physical finding in the absence of dysmorphic features?

A

Increased Weight for Height

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9
Q

In regards to pathological short stature, Turner’s, Trisomy 21, Russel-Silver, Noonan, Prader Willi, DiGeorge all have _____ Dysmorphic features

A

Proportionate

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10
Q

Growth Hormone is released in a _____ pattern

A

Pulsatile

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11
Q

Short Stature is defined as height less than _______

A

2 Standard Deviations Below the mean

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12
Q

How will Familial Short Stature show on the growth curve?

A

Consistently steady and below the curve, otherwise follows the normal shape

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13
Q

Levodopa, clonidine, glucagon, and arginie all stimulate ____ hormone

A

Growth

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14
Q

Obese patient due to endogenous boost of Glucocorticoids growth chart: will have an increase in weight with Heigh following which possible pattern?

A

LINEAR Growth failure

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15
Q

What height are klinefelter’s patients?

A

Tall

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16
Q

If there is pathological short stature, you frist look for _____ features

A

Dysmorphic

17
Q

How does the constitutional delay of growth differ from Familial short stature?

A
  • Constit shows as a “late bloomer”, where eventually they get to average.
  • The curve is shifted to the right
18
Q

SHOX gene deficiency is a common cause of ____ syndrome resulting in short stature

A

Turner

19
Q

IGF-1, IGFBP-3, and ALS are all released as a response to _______ hormone, which makes IGF-BP3 a good marker to measure

A

Growth

20
Q

Turner Syndrome is associated with short stature, ovarian failure, horseshoe kidney, and a higher risk of autoimmune diseases due to haploinsufficiency of the _____ gene

A

SHOX

“Turner is shocking!”