Lubitz Male Hypogonadism

Question 1

2 Causes of Hyper-Gonadotropic Hypogonadism

Answer 1

1. Klinefelter

2. Cryptoorrchidism

Question 2

Within each testis-lobule are two to four loops of seminiferous tubules. Each loop empties into an anastomosing network of tubules called the ______

Answer 2

Rete Testis

Question 3

Among the pituitary dysfunctions causing HYPOgonadotropic hypogonadism, is Hyper-_______ which inhibits GnRH

Answer 3

Prolactinemia

Question 4

Klinefelter’s is a genotype of _____ w/ what levels of T, LH/FSH?

Answer 4

XXY male w/ low T and High LH/FSH

Question 5

Sem Tubule —> Rete Testis –>efferent ductules –> _____

Answer 5

Head of epididymis

Question 6

Sertoli Cells express both _____ Receptor and _____ Receptor

Answer 6

• Androgen

- FSH

Question 7

XXY males results in small testis, low T, and HIGH LH/FSH in ______ Syndrome

Answer 7

Klinefelter’s

Question 8

Testosterone can be converted into a potent, nonaromatizable androgen, 5α-dihydrotestosterone (DHT), by the enzyme _____. This enzyme has Type 1 and Type 2, with Type 2 having the most notable, widespread effects

Answer 8

5α-reductase

Question 9

Leydig cells’ main function is to produce _____

Answer 9

Testosterone

“Dig that T”

Question 10

Leydig Cells express _____ Receptor

Answer 10

LH

Question 11

Inhibin is made from Sertoli cells and exclusively inhibits the production of _____

Answer 11

FSH

Question 12

Unlike the Zona Reticularis of the Adrenal, the Leydig cell expresses a Leydig cell-specific isoform of 17β-hydroxysteroid dehydrogenase (17βHSD3), which converts _______ to testosterone

Answer 12

androstenedione

Question 13

Without Testosterone, the male parts originating from the ______ duct still form

Answer 13

Mesonephric

Question 14

A small phallus means that the hypogonadism occurred when?

Answer 14

Pre-Pubertal

Question 15

4 Side effects of Testosterone Replacement

Answer 15

1. Dyslipidemia
2. Polycythemia
3. Gynecomastia
4. Growth of Prostate

Question 16

“Some Hormones Create Knockers” is a mnemonic for drugs that cause gynecomastia

Answer 16

• Spirinolactone
• Hormones
• Cimetidine
• Ketoconazole

Question 17

3 causes of hypo-gonadotropic hypogonadism

Answer 17

1. Kallman
2. Prader-willi
3. Pituitary adenoma

Question 18

Kallman syndrome, Parder-Willi Syndrome, and Pituitary adenomas all cause ______ gonadotropic hypogonadism

Answer 18

HYPO

Question 19

Pathophys of Kallmann-caused hypogonadotropic hypogonadism

Answer 19

GnRH neurons fail to travel along with smell receptors

Question 20

If you have Orchitis due to Mumps or HIV, what happens to T,LH,FSH levels?

Answer 20

• Low T
• High FSH/LH
  (Pituitary in tact)

Question 21

Key physical finding with Kallmann’s syndrome?

Answer 21

Anosmia

Question 22

Klinefelter syndrome, CryptoOrchidism, and trauma/autoimmune are 3 causes of ________ -gonadotropic hypogonadism

Answer 22

HYPER

Question 23

Eunuchoidism clues you that the hypogonadism occurred at what time?

Answer 23

Pre-Pruberty

Question 24

Four Additional functions of Chef Sertoli Cells

Answer 24

1. CYP19 Aromatase to make estradiol-17B
2. Androgen-Binding Protein (ABP)
3. Anti-Mullerian Hormone (AMH)
4. Inhibin (Just FSH Negative Feedback)

Question 25

Both LH and FSH act via which signaling pathway? (3 parts)

Answer 25

Gs-cAMP-PKA

Question 26

Cholesterol is converted to pregnenolone by CYP11A1 (cholesterol desmolase). Pregnenolone is then processed to progesterone, 17α-hydroxyprogesterone, and androstenedione by _____ and _____.

Answer 26

• 3β-hydroxysteroid dehydrogenase type 2 (3β-HSD2)

- 17hydroxylase/17,20-lyase (CYP17)