Gynecologic Malignancies Flashcards
Tumors of cervical myometrium may be benignly known as _____ or malignant known as _______
- Leiomyoma
- Leiomyosarcoma
There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?
Type 1
Key histo finding to indicate Leiomyosarcoma?
MORE MITOTIC FIGURES
There are 2 types of Endomet cancer. Which affects 55-65 yr olds vs 65-75 year olds?
- Type 1: 55-65
- Type 2: 65-75
“The higher number affects the higher number”
Why do leiomyomas get bigger during pregnancy?
They respond to estrogen
If there is very minimal bleeding after menopause, should you investigate it?
You’re god damn right you should
For gynecologic neoplasms, AGE and PROGNOSIS go together for 3 disorders. List the 3 starting with the youngest/best and ending with the oldest and worst
- Cervical (youngest & best)
- Endometrial
- Ovarian (oldest & worst)
Type 2 Endometrial cancer has a buttload of Finger-Papillary Projections as seen below. How does Type 1 present histologically (name 2 things)?
- Lose Stroma
- Packed glands
There are 2 types of Endometrial cancer. Which is linked to Atrophy and thin physique?
Type 2
The most common symptom of Endometrial Cancer is:
Post-Menopausal Bleeding
The outer cervix is squamous, the inner is Columnar. The junction is known as the ____ ____ and is a site for cancer
Transition Zone
Endometrial hyperplasia with _____ inactivation is linked up to 50% of HIGH risk lesions
PTEN
PTEN silencing or MLH1 silencing occurs in Type ____ endometrial cancers that lose their stroma
1
Two molecules silencing in Type 1 Endometrial cancer that loses stroma?
- PTEN
- MLH1
There are 2 types of Endometrial cancer. Which is linked to PTEN silencing and LYNCH Syndrome?
Type 1
Endometrial hyperplasia is caused by unopposed _____ and you should watch out for Type 1 Cancer
ESTROGEN
Type 2 endometrial Cancer is usually carcinoma, affects older women, is linked to a p53 mutation and histologically will show _______
Finger-Like Papillary Projections
Rb and p21 are tumor suppressors. Which HPV Oncoprotein binds these two guys?
E7
Finding cells that respond to estrogen outside of uterine lining indicates likely ________
Endometriosis
2 Key findings that indicate Endometritis instead of Endometriosis
- Fever
- Abnormal Uterine Bleeding
There are 2 types of Endometrial cancer. Which is linked to Unopposed estrogen, obesity, HTN, and Diabetes?
Type 1
There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?
Which is linked to P53 and aneuploidy?
For Gynecologic neoplasms, _____ cancer is the most common
Endometrial
When you find endometrium in the muscle layer it is known as ______-Mosis and can only really be ID”d by painful menstruation
Adeno
