Gynecologic Malignancies

Question 1

Tumors of cervical myometrium may be benignly known as _____ or malignant known as _______

Answer 1

• Leiomyoma
• Leiomyosarcoma

Question 2

There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?

Answer 2

Type 1

Question 3

Key histo finding to indicate Leiomyosarcoma?

Answer 3

MORE MITOTIC FIGURES

Question 4

There are 2 types of Endomet cancer. Which affects 55-65 yr olds vs 65-75 year olds?

Answer 4

• Type 1: 55-65
• Type 2: 65-75

“The higher number affects the higher number”

Question 5

Why do leiomyomas get bigger during pregnancy?

Answer 5

They respond to estrogen

Question 6

If there is very minimal bleeding after menopause, should you investigate it?

Answer 6

You’re god damn right you should

Question 7

For gynecologic neoplasms, AGE and PROGNOSIS go together for 3 disorders. List the 3 starting with the youngest/best and ending with the oldest and worst

Answer 7

1. Cervical (youngest & best)
2. Endometrial
3. Ovarian (oldest & worst)

Question 8

Type 2 Endometrial cancer has a buttload of Finger-Papillary Projections as seen below. How does Type 1 present histologically (name 2 things)?

Answer 8

• Lose Stroma
• Packed glands

Question 9

There are 2 types of Endometrial cancer. Which is linked to Atrophy and thin physique?

Answer 9

Type 2

Question 10

The most common symptom of Endometrial Cancer is:

Answer 10

Post-Menopausal Bleeding

Question 11

The outer cervix is squamous, the inner is Columnar. The junction is known as the ____ ____ and is a site for cancer

Answer 11

Transition Zone

Question 12

Endometrial hyperplasia with _____ inactivation is linked up to 50% of HIGH risk lesions

Answer 12

PTEN

Question 13

PTEN silencing or MLH1 silencing occurs in Type ____ endometrial cancers that lose their stroma

Answer 13

1

Question 14

Two molecules silencing in Type 1 Endometrial cancer that loses stroma?

Answer 14

1. PTEN
2. MLH1

Question 15

There are 2 types of Endometrial cancer. Which is linked to PTEN silencing and LYNCH Syndrome?

Answer 15

Type 1

Question 16

Endometrial hyperplasia is caused by unopposed _____ and you should watch out for Type 1 Cancer

Answer 16

ESTROGEN

Question 17

Type 2 endometrial Cancer is usually carcinoma, affects older women, is linked to a p53 mutation and histologically will show _______

Answer 17

Finger-Like Papillary Projections

Question 18

Rb and p21 are tumor suppressors. Which HPV Oncoprotein binds these two guys?

Answer 18

E7

Question 19

Finding cells that respond to estrogen outside of uterine lining indicates likely ________

Answer 19

Endometriosis

Question 20

2 Key findings that indicate Endometritis instead of Endometriosis

Answer 20

1. Fever
2. Abnormal Uterine Bleeding

Question 21

There are 2 types of Endometrial cancer. Which is linked to Unopposed estrogen, obesity, HTN, and Diabetes?

Answer 21

Type 1

Question 22

There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?

Answer 22

Which is linked to P53 and aneuploidy?

Question 23

For Gynecologic neoplasms, _____ cancer is the most common

Answer 23

Endometrial

Question 24

When you find endometrium in the muscle layer it is known as ______-Mosis and can only really be ID”d by painful menstruation

Answer 24

Adeno

Question 25

For cervical cancer, what is the key cell type that is a histological give away?

Answer 25

Koilocytes “Halo Cells”

Question 26

p53 is a tumor suppressor. Which HPV oncoprotein blocks it to promote cancer?

Answer 26

E6

Question 27

Advanced Cervical Cancer has a triad ____, pain and _____

Answer 27

1. Leg Edema
2. Pain
3. Hydronephrosis

Question 28

“PALM” ddx for Abnormal uterine bleeding?

Answer 28

Polyp

Adenoma

Leiomyoma

Malignancy

Question 29

Cervical Cancer is a ______ cell- intraeptheilial lesion that hit cells at the _____ layer!

Answer 29

• Squamous
• Basal

Question 30

There are 2 types of Endometrial cancer. Which is linked to Serous and Clear cells?

Answer 30

Type 2