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RWJ Endo Repro > Gynecologic Malignancies > Flashcards

Gynecologic Malignancies Flashcards

1
Q

Tumors of cervical myometrium may be benignly known as _____ or malignant known as _______

A
  • Leiomyoma
  • Leiomyosarcoma
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2
Q

There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?

A

Type 1

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3
Q

Key histo finding to indicate Leiomyosarcoma?

A

MORE MITOTIC FIGURES

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4
Q

There are 2 types of Endomet cancer. Which affects 55-65 yr olds vs 65-75 year olds?

A
  • Type 1: 55-65
  • Type 2: 65-75

“The higher number affects the higher number”

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5
Q

Why do leiomyomas get bigger during pregnancy?

A

They respond to estrogen

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6
Q

If there is very minimal bleeding after menopause, should you investigate it?

A

You’re god damn right you should

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7
Q

For gynecologic neoplasms, AGE and PROGNOSIS go together for 3 disorders. List the 3 starting with the youngest/best and ending with the oldest and worst

A
  1. Cervical (youngest & best)
  2. Endometrial
  3. Ovarian (oldest & worst)
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8
Q

Type 2 Endometrial cancer has a buttload of Finger-Papillary Projections as seen below. How does Type 1 present histologically (name 2 things)?

A
  • Lose Stroma
  • Packed glands
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9
Q

There are 2 types of Endometrial cancer. Which is linked to Atrophy and thin physique?

A

Type 2

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10
Q

The most common symptom of Endometrial Cancer is:

A

Post-Menopausal Bleeding

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11
Q

The outer cervix is squamous, the inner is Columnar. The junction is known as the ____ ____ and is a site for cancer

A

Transition Zone

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12
Q

Endometrial hyperplasia with _____ inactivation is linked up to 50% of HIGH risk lesions

A

PTEN

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13
Q

PTEN silencing or MLH1 silencing occurs in Type ____ endometrial cancers that lose their stroma

A

1

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14
Q

Two molecules silencing in Type 1 Endometrial cancer that loses stroma?

A
  1. PTEN
  2. MLH1
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15
Q

There are 2 types of Endometrial cancer. Which is linked to PTEN silencing and LYNCH Syndrome?

A

Type 1

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16
Q

Endometrial hyperplasia is caused by unopposed _____ and you should watch out for Type 1 Cancer

A

ESTROGEN

17
Q

Type 2 endometrial Cancer is usually carcinoma, affects older women, is linked to a p53 mutation and histologically will show _______

A

Finger-Like Papillary Projections

18
Q

Rb and p21 are tumor suppressors. Which HPV Oncoprotein binds these two guys?

A

E7

19
Q

Finding cells that respond to estrogen outside of uterine lining indicates likely ________

A

Endometriosis

20
Q

2 Key findings that indicate Endometritis instead of Endometriosis

A
  1. Fever
  2. Abnormal Uterine Bleeding
21
Q

There are 2 types of Endometrial cancer. Which is linked to Unopposed estrogen, obesity, HTN, and Diabetes?

A

Type 1

22
Q

There are 2 types of Endometrial cancer. Which is linked to Endometrioid cells?

A

Which is linked to P53 and aneuploidy?

23
Q

For Gynecologic neoplasms, _____ cancer is the most common

A

Endometrial

24
Q

When you find endometrium in the muscle layer it is known as ______-Mosis and can only really be ID”d by painful menstruation

A

Adeno

25
Q

For cervical cancer, what is the key cell type that is a histological give away?

A

Koilocytes “Halo Cells”

26
Q

p53 is a tumor suppressor. Which HPV oncoprotein blocks it to promote cancer?

A

E6

27
Q

Advanced Cervical Cancer has a triad ____, pain and _____

A
  1. Leg Edema
  2. Pain
  3. Hydronephrosis
28
Q

“PALM” ddx for Abnormal uterine bleeding?

A

Polyp

Adenoma

Leiomyoma

Malignancy

29
Q

Cervical Cancer is a ______ cell- intraeptheilial lesion that hit cells at the _____ layer!

A
  • Squamous
  • Basal
30
Q

There are 2 types of Endometrial cancer. Which is linked to Serous and Clear cells?

A

Type 2

RWJ Endo Repro (26 decks)

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