Wk 4 Viral Skin Infections Flashcards
Type I virus genome type
dsDNA
Type I virus: enveloped/not enveloped
enveloped
Two types of viral life cycles
latent, lytic
Where can the viral genome be found in host cells carrying the latent virus?
bound to host genome
Three subfamiles of herpesviruses
alpha, beta, gamma
α-herpesviruses
HSV-1, HSV-2, varicella-zoster
β-herpesviruses
human cytomegalovirus (HCMV, HHV-6, HHV-7)
γ-herpesviruses
Eptstein-Barr, Kaposi sarcoma-associated herpesvirus (KSHV)
Stage of viral life cycle, T-independent
attachment
Penetration of virus: required
enzymatic activity @ ~ body temperature
How can one tell the difference between host and viral protein synthesis?
it is not possible
Where do new varions get their lipid coat from?
host nuclear membrane
What type of T-cells are activated in response a viral infection?
CD8+ T-cells
What type of MHC receptors are utilized in a viral immune response?
MHC Class I
Two phenomenon that contribute to viral infection symptoms
lysis of host cells + host immune inflammatory response
Varicella-Zoster Virus: mode(s) of transmission
respiratory droplets + direct contact
What type of cells do alphaherpesviruses infect?
nerve (neurotropic)
Refuge for zoster viruses
dorsal root ganglia
Smallpox: stages of differentiation
all pustules at same differentiation level
Picornaviruses
class IV, nonenveloped
Hand, foot, and mouth disease causative agent
coxsackievirus (usually A)
Where does coxsackie virus usually cause a rash first?
mouth
How to remember maculopapular rashes
“the odds plus 6”
Measles “first disease”
Group V, ssRNA - sense
