Wk 4 Viral Skin Infections

Question 1

Type I virus genome type

Answer 1

dsDNA

Question 2

Type I virus: enveloped/not enveloped

Answer 2

enveloped

Question 3

Two types of viral life cycles

Answer 3

latent, lytic

Question 4

Where can the viral genome be found in host cells carrying the latent virus?

Answer 4

bound to host genome

Question 5

Three subfamiles of herpesviruses

Answer 5

alpha, beta, gamma

Question 6

α-herpesviruses

Answer 6

HSV-1, HSV-2, varicella-zoster

Question 7

β-herpesviruses

Answer 7

human cytomegalovirus (HCMV, HHV-6, HHV-7)

Question 8

γ-herpesviruses

Answer 8

Eptstein-Barr, Kaposi sarcoma-associated herpesvirus (KSHV)

Question 9

Stage of viral life cycle, T-independent

Answer 9

attachment

Question 10

Penetration of virus: required

Answer 10

enzymatic activity @ ~ body temperature

Question 11

How can one tell the difference between host and viral protein synthesis?

Answer 11

it is not possible

Question 12

Where do new varions get their lipid coat from?

Answer 12

host nuclear membrane

Question 13

What type of T-cells are activated in response a viral infection?

Answer 13

CD8+ T-cells

Question 14

What type of MHC receptors are utilized in a viral immune response?

Answer 14

MHC Class I

Question 15

Two phenomenon that contribute to viral infection symptoms

Answer 15

lysis of host cells + host immune inflammatory response

Question 16

Varicella-Zoster Virus: mode(s) of transmission

Answer 16

respiratory droplets + direct contact

Question 17

What type of cells do alphaherpesviruses infect?

Answer 17

nerve (neurotropic)

Question 18

Refuge for zoster viruses

Answer 18

dorsal root ganglia

Question 19

Smallpox: stages of differentiation

Answer 19

all pustules at same differentiation level

Question 20

Picornaviruses

Answer 20

class IV, nonenveloped

Question 21

Hand, foot, and mouth disease causative agent

Answer 21

coxsackievirus (usually A)

Question 22

Where does coxsackie virus usually cause a rash first?

Answer 22

mouth

Question 23

How to remember maculopapular rashes

Answer 23

“the odds plus 6”

Question 24

Measles “first disease”

Answer 24

Group V, ssRNA - sense

Question 25

Rubella “third disease”

Answer 25

Group IV, ssRNA + sense

Question 26

Erythema infectiosum “fifth disease” causative organism

Answer 26

parovirus B19, gives “slapped cheek” appearance

Question 27

Complication of fifth disease

Answer 27

spontaneous abortion in preg women in first trimester

Question 28

Roseola “sixth disease” presentation

Answer 28

fever up to 104, on day 4 rash on trunk –> extremities

Question 29

HPV class

Answer 29

Group I, nonenveloped