Wk 3 Immunology of the Skin Flashcards
Type I hypersensitivity
- onset
- serological manifestations
- quick onset ~15 min
- IgE production
Physiology of type I hypersensitivity rxn
2 IgE molecules come together –>
degranulation event on mast cells –>
histamine release
Common name type I hypersensitivity
allergic rxn
Common name type II hypersensitivity
cross rxn
Type II hypersensitivity
- onset
- serological manifestations
- delayed onset
- IgG or IgM production
Result of type II hypersensitivity rxn
NK cell activation
Type III hypersensitivity
-serological manifestations
-high amounts of antibodies not cleared out
Type III hypersensitivity common name
immune complex rxn
Type III hypersensitivity physiology
large amounts of antibodies not cleared from circulation, attach to endothelium of blood vessels causing damage to blood vessels
Type IV hypersensitivity
- onset
- serological manifestations
- delayed onset
- T-cell mediated disease
Example type I hypersensitivity
allergic rxn to proteins
Example type II hypersensitivity
autoimmune rxns
Example type III hypersensitivity
chronic glomerulonephritis
Example type IV hypersensitivity
contact sensitivity
What cell type is an undifferentiated T-cell?
Th0
