WILM'S TUMOR Flashcards
Wilms tumour
Wilms tumour (nephroblastoma) is a malignant embryonal tumour of renal tissue
Wilms tumour is the ……… commonest cancer among children in Ghan
4th
About 80% of children with Wilms tumour present before………. of age
5years
Congenital anomalies associated with Wilms tumour
Hemihypertrophy
Absence of the iris (aniridia)
Cause of Wilms tumor
Sporadic gene mutation
Symptoms of Wilms tumor
Visible and or palpable abdominal mass
Fever
Blood in urine
Investigations in Wilms tumor
Abdominal ultrasound scan
Abdominal CT scan
Chest X-ray
Full Blood Count
Blood Urea, electrolytes and creatinine
Pre-operative treatment of Wilms tumor
Vincristine, IV,
And
Actinomycin D, IV,
And
Doxorubicin, IV, (if presence of metastases)
Non-pharmacological interventions in Wilms tumor
Nephrectomy
Radiotherapy post-surgery for advanced cases
Treatment objectives in Wilms tumor
To obtain long term cure
To provide adequate supportive and palliative care
Signs of Wilms tumor
Abdominal mass
Haematuria
Hypertension
Associated congenital anomalies
Post-operative treatment of Wilms tumor
Vincristine, IV,
Actinomycin D, IV,
Doxorubicin, IV, (depending on stage and risk category)
Or
Carboplatin, IV,
Etoposide, IV,
Doxorubicin, IV, Cyclophosphamide IV in combination (For high risk tumours)
Management of chemotherapy associated vomiting in Wilms tumor
Metoclopramide
or
Granisetron
or
Ondansetron
Treatment of chemotherapy associated febrile neutropenia in Wilms tumor
Ceftriaxone, IV, 100 mg/kg daily
And
Gentamicin, IV, 5 mg/kg daily
And (if still febrile after 48 hours, add)
Cloxacillin, IV, 25-50 mg/kg 6 hourly
And (if still febrile after 5 days, add)
Fluconazole, oral, 10 mg/kg daily
Treatment of chemotherapy associated anaemia and thrombocytopenia in Wilms tumor
Blood and blood product transfusions
