MALIGNANT LYMPHOMA

Question 1

Malignant lymphoma

Answer 1

Group of disorders characterized by malignant proliferation of lymphoid tissue usually presenting as lymph node swellings

Question 2

Difference between HL and non-HL

Answer 2

HL has Reed Sternberg cells but non-HL does not

Question 2

Cllinical variants of Burkitt’s lymphoma

Answer 2

endemic
sporadic
immunodeficiency associated forms.

Question 2

Types of lymphoma

Answer 2

Hodgkin’s lymphoma
Non-Hodgkin’s lymphoma

Question 2

Burkitt’s lymphoma

Answer 2

It’s a highly aggressive B-cell non-Hodgkin lymphoma (NHL)

Question 3

Endemic form of Burkitt’s lymphoma is
found in tropical and malaria endemic regions like Ghana and commonly
presents as …………..

Answer 3

Jaw swelling with loosening of the associated teeth

Question 3

Commonest childhood malignancy in Ghana

Answer 3

Burkitt’s lymphoma

Question 4

Peak age and sexual variation of Burkitt’s lymphoma

Answer 4

4-7 years, more common in males

Question 4

Agents associated with Malignant lymphoma

Answer 4

Chronic antigenic stimulation by Helicobacter pylori infection in gastric lymphoma
Viruses e.g. herpes virus 8, epstein-barr virus, HTLV-1
Chemicals e.g. pesticides, herbicides
Wood dust

Question 5

Signs of malignant lymphoma

Answer 5

Lymph node biopsy (of a significantly enlarged node)
Fine needle aspiration (in Burkitts)
FBC and blood film comment
Chest X-ray, abdominal USG, CT scan when necessary
Bone marrow aspirate and trephine biopsy

Question 6

Symptoms of maligant lymphoma

Answer 6

Lymph node swelling which may wax and wane
Jaw swelling (in Burkitts)
Fever
Night sweats
Weight loss
Easy fatiguability
Abdominal distension, intestinal obstruction (in abdominal lymphomas)