PEPTIC ULCER DISEASE Flashcards

1
Q

……. Ulcer is more common

A

Duodenal

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2
Q

Which type of peptic ulcers occur more often in younger adults

A

Duodenal

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3
Q

Which type of gastric ulcers usually occur after middle age

A

Gastric

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4
Q

Which type of gastric ulcer is more oikely to be malignant

A

Gastric

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5
Q

Complications of peptic ulcers

A

Bleeding
Perforation
Gastric outlet obstruction

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6
Q

Causes of peptic ulcer

A

H. pylori
Excessive acid secretion
Inadequate protection of stomach and duodenum
Drug-induced

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7
Q

Drugs that can cause ulcers

A

NSAIDs
Corticosteroids

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8
Q

Symptoms of peptic upcer

A

Pain in epigastrium or right hypochondrium
Vomiting
Periumbilical pain in children

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9
Q

Nature of pain in gastric ulcer

A

Pain is worsened by food and may be relieved by vomiting

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10
Q

Nature of pain in duodenal ulcer

A

Pain is relieved by food and occurs when patient is hungry

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11
Q

Weight loss occurs in ….. ulcer

A

Gastric ulcer

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12
Q

Weight gain occurs in …. ulcer

A

Duodenal

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13
Q

Investigations in peptic ulcer disease

A

Hemoglobin
H. Pylori stool antigen
Endoscopy (esophago-gastro-duodenoscopy)
Barium meal in the absence of endoscopy
Stool examination to exclude intestinal parasites

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14
Q

Treatment objectives in peptic ulcer

A

To relieve pain and reduce gastric acid secretion
To eradicate H. pylori if present
To promote healing of the ulcer
To prevent recurrence of the ulcer
To prevent and manage complications

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15
Q

Non-pharmacological interventions for peptic ulcer

A

Reduce alcohol and tobacco intake
Avoid foods that aggravate pain
Reduce anxiety and stress
Surgical treatment

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16
Q

Pharmacological treatment for dyspepsia

A

1st line
Magnesium trisilicate 15ml 8 hourly
Or
Aluminium hydroxide 500mg 6 hourly

2nd Line
Omeprazole 20mg daily for 4 weeks

17
Q

Avoid taking antacids within ……… of taking PPI

A

2 hours

18
Q

Treatment for NSAID associated ulcer

A

Esomeprazole 20mg daily for 4 weeks
Or
Omeprazole 20mg daily for 4 weeks
Or
Pantoprazole 20-40mg daily for 4 weeks

19
Q

Treatment for bleeding peptic ulcer

A

Esomeprazole IV
40mg daily
Or
Omeprazole IV
40mg 12 hourly for up to 15 days

20
Q

How long should H pylori eradication therapy be given for

A

10-14 days

21
Q

H. Pylori eradication regimen

A

Esomeprazole PO 20mg 12 hourly or Omeprazole 20mg 12 hourly or Pantoprazole 40mg 22 hourly
+ Amoxicillin 1g 12 hourly + Clarithromycin 500mg 12 hourly

Or

Esomeprazole PO 20mg 12 hourly or Omeprazole 20mg 12 hourly or Pantoprazole 40mg 22 hourly
+ Amoxicillin 1g 12 hourly + Clarithromycin 500mg 12 hourly

Or

Omeprazole 20mg 12 hourly + Amoxicillin 500mg 8 hourly + Metronidazole 400mg 8 hourly