White Blood Cells , Lymphnodes , Spleen , Thymus

Question 1

What do you call the characteristic cells found in Hodgkin lymphoma?

Answer 1

Reed-Sternberg (RS) cells

Question 2

This is the phenomenon in which certain types of lymphoma progress to diffuse large B-cell lymphoma. (DLBCL)

Answer 2

Ritcher Phenomenon

Question 3

What is the most common non-Hodgkin lymphoma?

Answer 3

Diffuse large B-cell lymphoma (DLBCL)

Question 4

Which type of lymphoma is regarded as one of the fastest growing human tumors? What do you call the pattern found in this disease that involves non-neoplastic tingle-body macrophages dotting sheets of neoplastic lymphoid cells?

Answer 4

Burkitt lymphoma “Starry Sky “ Pattern

Question 5

What is the most common cancer in children?

Answer 5

ALL - Acute Lymphoblastic Leukemia / Lymphoma

Question 6

This is a genetic mutation that identifies Acute Promyelocytic Leukemia ( APML)

Answer 6

t(15; 17)

Question 7

The Philadelphia chromosome is characteristically associated with this disease.

Answer 7

Chronic Myeloid Leukemia

Question 8

This is the type of Hodgkin lymphoma that is associated with the worst prognosis.

Answer 8

Lymphocyte Depleted Hodgkin Lymphoma

Question 9

This disease is characterized by plasmacytomas, multiple lytic “punched-out” bone lesions, hypercalcemia, renal failure, and deficiencies in humoral immunity.

Answer 9

Multiple Myeloma

Question 10

Birbeck granules are pentalaminar tubules with dilated terminal ends; tennis racket -like ; are pathognomonic for this disease.

Answer 10

Langerhans Cell Histiocytosis

Question 11

Term used in decreased number of circulating leukocytes; most commonly involves neutrophils.

Answer 11

Neutropenia

Question 12

Marked neutropenia with consequent increased susceptibility to bacterial and fungal infections; most common cause is drug toxicity.

Answer 12

Agranulocytosis

Question 13

An increase in the number of white cells in the blood in a variety of inflammatory states caused by microbial and non-microbial stimuli that may mimic leukemia?

Answer 13

1. Reactive leukocytosis
2. Leukemoid reaction

Note: increased LAP Score is expected of leukemoid reaction because LAP is a product of normal leukocytes.

Question 14

Lymph node enlargement as immune response to antigenic stimulation , histology usually nonspecific; depends on duration of disease and type of offending agent.

Answer 14

Lymphadenitis

Question 15

Neoplastic proliferation of white cells wherein the neoplastic white cells populate the peripheral blood and bone marrow, which leads to peripheral blood cytopenias. Clinical manifestations depend on the cell line/s affected.

Answer 15

Leukemia

Question 16

Neoplastic proliferation of white cells that presents as discrete tissue masses.

Answer 16

Lymphoma

Question 17

Chronic lymphocytic leukemia is almost always characterized by the proliferation of what cells?

Answer 17

B-cells

Question 18

Clinical features of anemia, thrombocytopenia , and cytokine storm with systemic activation of CD8+ and macrophages which phagocytose blood cell progenitors in the marrow?

Answer 18

Hemophagocytic lymphohistiocytoma

Question 19

Which immunoglobulin is low in hypogammaglobuminemia?

Answer 19

IgG

Question 20

Condition in which a blast cell with an Auer rod is seen?

Answer 20

AML

Question 21

Urine casts that can be a normal finding with dehydration and exercise?

Answer 21

Hyaline casts

Question 22

Urine casts found in diuretic therapy?

Answer 22

Hyaline casts

Question 23

Urine casts found in Glomerulonephritis, Hypertension emergency?

Answer 23

RBC Casts

Question 24

Urine casts found in Tubulointerstitial inflammation, Acute pyelonephritis, Transplant rejection.

Answer 24

WBC Casts

Question 25

Urine casts found in Acute Tubular Necrosis , muddy brown appearance

Answer 25

Granular Casts

Question 26

Urine casts found in Nephrotic Syndrome associated with Maltese Cross Sign?

Answer 26

Fatty Casts ( Oval Fat Bodies)

Question 27

Urine casts found in End-stage Renal Disease / Chronic Kidney Disease?

Answer 27

Waxy Casts