Kidney Flashcards
This glomerular syndrome is characterized by hematuria, azotemia, variable proteinuria, edema, and hypertension.
Nephritic syndrome
This glomerular syndrome is characterized by proteinuria , hypoalbuminemia, hyperlipidemia and lipiduria.
Nephrotic syndrome
What is the most common cause of nephritic syndrome in children?
What is the electron microscopic finding in this disease?
Post-streptococcal acute glomerulonephritis (PSAGN) ;
Subepithelial humps on glomerular basement membrane (GBM)
What is the histologic hallmark for rapidly progressing glomerulonephritis (RPGN)?
Presence of crescents
- proliferation of parietal epithelial cells admixed with leukocytes infiltrating the glomerulus.
Which disease is characterized by the presence of antibodies against the non-collagenous domain of a3 chain of type IV collagen, which is an antigen found in both alveoli and glomerular basement membrane?
Good pasture Syndrome ( RPGN Type I)
What is the most common cause of nephrotic syndrome in children?
Minimal change disease
What is the most common cause of nephrotic syndrome in adults?
Focal segmental glomerulosclerosis (FSGS)
The electron microscopy findings for this disease include lamina densa that is permeated by a ribbon-like extremely electron dense structure.
Dense deposit disease ( MPGN Type II)
This is a common type of glomerulonephritis worldwide and involves IgA deposition limited to the kidneys.
IgA nephropathy ( Bergers Disease)
This hereditary syndrome is characterized by the defective assembly of type IV collagen , leading to abnormalities in the eyes , ears, and kidney.
Alport Syndrome
Struvite stones are associated with infection from which pathogen?
Proteus
Where is the most common site of metastasis for renal cell carcinoma?
Lung >50%
What is the cytogenic origin for chromophobe renal cell carcinoma?
Intercalated cells of collecting ducts
What is the most common malignant kidney tumor?
Renal cell carcinoma
What is the second most common malignant kidney tumor?
Wilms tumor
11 / M with prior history of sore throat presents with hematuria and hypertension. Renal biopsy: Lumpy bumpy appearance on immunoflourescence , Subepithelial humps on electron microscopy. Diagnosis?
Post-streptococcal acute glomerulonephritis (PSAGN)
30/F with prior history of sore throat presents with hematuria, hypertension, oliguria, and azotemia. Renal biopsy: Crescents. Diagnosis?
Rapidly Progressing Glomerulonephritis, Type II
20/M with hematuria and hearing loss. Renal biopsy : Basket weave appearance on electron microscopy. Diagnosis?
Alport Syndrome
20/ M hemoptysis and hematuria. Renal biopsy : Crescents with linear pattern of immunoflourescence. Diagnosis?
Goodpasture syndrome
60/M known case of multiple myeloma presents with oliguria and azotemia. Renal biopsy: Pink to blue masses obstructing tubular lumina. Diagnosis?
Light Chain Cast Nephropathy
Which of the following antibody is found in post-streptococcal glomerulonephritis?
Anti-streptolysin or Anti-hyaluronidase
Post-tonsillectomy patient brought to the ER because of bleeding at the operative site. He vomited copious amounts of blood. If he would develop renal failure , what type would nost probably occur?
Pre-renal failure due to blood loss
Condition with distinctive crescents formed by proliferation of parietal cells and margination of monocytes and macrophages in the urinary space in light microscopy?
Rapidly progressive glomerulonephritis
Pathology of a rapidly progressive glomerulonephritis with concomitant diffuse pulmonary hemorrhage?
Presence of circulating anti-glomerular basement membrane antibodies , Goodpasture syndrome
Which of the following are typical symptoms of kidney failure?
- Pruritus
- Hallucinations
- Insomnia
Causes of glomerulonephritis show formation of crescents. These are due to proliferation of ?
Bowmans capsule epithelial cells
