Diseases Of The Immune System Flashcards
Anaphylaxis is what type of hypersensitivity reaction?
Type I ( Immediate) Hypersensitivity
Erythroblastosis fetalis is what type of hypersensitivity?
Type II ( Antibody-mediated) Hypersensitivity
Type III Hypersensitivity reactions are generally systemic , except for?
Arthus reaction
Arthus reaction : acute, localized inflammatory response that typically occurs after vaccination.
Psoriasis is what type of hypersensitivity?
Type IV ( T-cell mediated) hypersensitivity
What is the best screening test for SLE and is correlated with disease activity?
Anti-dsDNA
What is the triad that comprises Sjorgen Syndrome?
- Dry eyes ( keratoconjunctivitis sicca)
- Dry mouth (xerostomia)
- Other connective tissue disorders ( rheumatoid arthritis)
Name the components of CREST Syndrome?
- Calcinosis
- Raynaud phenomenon
- Esophageal dysmotility
- Sclerodactyly
- Telangiectasia
Which antibody is present in 10- 20% of diffuse scleroderma
Anti-Scl 70
Which disease is characterized by recurrent bacterial and enteroviral infections after 6 months?
X-linked (Burton) agammaglobulinemia
Which disease is characterized by a triad of thrombocytopenia, recurrent infections, and eczema?
Wiskott-Aldrich Syndrome
Which disease is characterized by a triad of thrombocytopenia, recurrent infections, and eczema?
Wiskott- Aldrich Syndrome
What is the antibody associated with mixed connective tissue disease?
Anti-U1-ribonucleoprotein (anti-U1-RNP)
Which organ is the most commonly affected in amyloidosis and represents the most serious form of organ involvement?
Kidney
What facilitates the attachment of the HIV virus to host cells? What facilitates fusion?
gp120-attachment;
gp41-fusion
Vascular dilatation, edema, smooth muscle contraction, mucus production, tissue injury, and inflammation are characteristic of this type of hypersensitivity?
Type I ( Immediate IgE- mediated)
Phagocytosis and lysis of cells, inflammation, and functional derangements without evidence of cell tissue injury ( in some disease) are characteristic of this type of hypersensitivity?
Type II ( Antibody mediated)
Inflammation and necrotizing vasculitis ( fibrinoid necrosis) are characteristic of this type of hypersensitivity?
Type III ( Immunecomplex mediated)
Perivascular cellular infiltrates, edema, granuloma formation, and cell destruction are characteristic of this type of hypersensitivity?
Type IV ( T-cell mediated / Delayed)
32/F with difficulty in breathing , bilateral elbow joint pains , and rash after sun exposure. CBC shows low hemoglobin and reticulocytosis. ANA titer is positive with peripheral rim pattern . What is the diagnosis?
SLE Systemic Lupus Erythematosus
Fundamental defect in SLE?
Failure of mechanisms of self-tolerance
Mechanism of organ damage in SLE?
Type III (most) .
Type II - opsonization and phagocytosis , hematologic manifestations)
Main pathogenic mechanism of autoantibody formation in SLE?
Inadequate clearance of apoptotic bodies that increase nuclear antigen burden.