Liver & Gallbladder

Question 1

Which autoimmune cholangiopathy is characterized by having a female predilection , cirrhosis with garland-shaped cirrhotic nodules , and is associated with an increased risk for hepatocellular carcinoma?

Answer 1

Primary biliary cholangitis

Question 2

This disease has male predilection , has radiographic findings of strictures and beading of large bile ducts and increase risks of lithiasis and cholangiocarcinoma.

Answer 2

Primary sclerosing cholangitis

Question 3

What do you call the acidophilluc apoptotic bodies that signify irreversible liver changes?

Answer 3

Councilman bodies

Question 4

This is the diffuse transformation of the liver into regenerating parenchymal nodules, surrounded by dense bands of scar , with variable degrees of vascular shunting.

Answer 4

Cirrhosis

Question 5

What is the common cause of portal hypertension and ascites?

Answer 5

Cirrhosis

Question 6

What is the most common cause of acute liver failure needing transplantation in the US?
Which metabolite of this compound is hepatotoxic?

Answer 6

Acetaminophen overdose, NAPQI

Question 7

This is an autosomal recessive disorder characterized by impaired copper excretion into bile and incorporation to ceruloplasmin.

Answer 7

Wilson Disease

Question 8

What is the tumor marker for hepatocellular carcinoma?

Answer 8

a- feto protein

Question 9

What are the three main risk factors for developing cholelithiasis?

Answer 9

3 Fs
Fat
Female
Forty

Question 10

What is the most common histology for gallbladder cancer?

Answer 10

Adenocarcinoma

Question 11

Liver biopsy of patient with gallstones shows a bile-stained nodular liver. Microscopic examination shows irregular jigsaw puzzle liver nodules separated by fibrous bands. Diagnosis?

Answer 11

Secondary Biliary Cirrhosis

Question 12

Most common route to hepatic failure and end point of relentless chronic hepatitis ending in cirrhosis is?

Answer 12

Chronic liver disease

Question 13

Jaundice occurs when the balance between bilirubin production and clearance in disturbed by the following mechanisms? (4)

Answer 13

1. Increased hepatocellular excretion
2. Impaired bile flow
3. Increase in portal venous blood flow
4. Reduced hepatocyte uptake

Question 14

A patient with advanced cirrhosis who had been diagnosed with hepatic encephalopathy would most likely manifest which symptom?

Answer 14

Hand tremors

Question 15

Deficiency of this enzyme causes the liver cells to store glycogen ?

Answer 15

Glucose - 6- phosphatase