Red Blood Cell & Bleeding Disorders

Question 1

All intrinsic types of hemolytic anemia are extravascular except for?

Answer 1

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Question 2

Which condition is under the intrinsic type of hemolytic anemia but exhibits both intra- and extravascular hemolysis?

Answer 2

Glucose-6-phosphate dehydrogenase (G-6PD) Deficiency

Question 3

This disease is characterized by defects in membrane skeleton proteins, specifically spectrin, ankyrin, band 3 and Band 4,2.

Answer 3

Hereditary Spherocytosis

Question 4

These are found in asplenic G6PD deficiency patients and are derived from hemoglobin?

Answer 4

Heinz bodies

Question 5

These are found in asplenic sickle cell anemia patients and are composed of nuclear remnants.

Answer 5

Howell-Jolly Bodies

Question 6

This disease is characterized by having 3 copies of the abnormal a-globin gene.

Answer 6

HbH disease

Question 7

This type of immunohemolytic anemia occurs postinfection and is mainly due to IgM.

Answer 7

Cold agglutinin type

Question 8

Name the two vitamins deficiency that cause macrocytic megaloblastic anemia?

Answer 8

Vitamin B12 & B9

Question 9

What are the components of thrombotic thrombocytopenic purpura (TTP) ?
What cell product is decreased in this condition?

Answer 9

1. Microangiopathic Hemolytic Anemia
2. Thrombocytopenia
3. Renal failure
4. Fever
5. Neurologic manifestations
6. ADAMTS13

Question 10

This is the most common adverse reaction of blood transfusion?

Answer 10

Febrile Non-hemolytic Transfusion Reaction (FNHTR)

Question 11

What is called Christmas disease ? What is the clotting factor that is lacking in this condition?

Answer 11

Hemophilia B, Factor IX

Question 12

This condition is characterized by bilateral adrenal hemorrhage secondary to fibrin thrombi?

Answer 12

Waterhouse - Freidrichsen Syndrome

Question 13

5/F presents with fever , cough, and wheezing consistent with respiratory synctal virus infection. The patient has anemia and cola-colored urine. Donath-Landsteiner test is positive. What is the diagnosis?

Answer 13

Paroxysmal Cold Hemoglobinuria

Question 14

36/F known case of systemic Lupus Erythematous presents with easy fatigability. CBC shows reticulocytosis. Direct Coombs Test: Positive. What’s the diagnosis?

Answer 14

Autoimmune Hemolytic Anemia (AIHA)

Question 15

Type of immune thrombocytopenic purpura seen in children after an acute infection, which resolves spontaneously.

Answer 15

Acute ITP

Question 16

Type of genetic mutation that causes beta thalassemia?

Answer 16

Point mutation

Question 17

Causes anemia in sickle cell disease ?

Answer 17

Consumption of red cells by splenic macrophages

Question 18

Elevated hemoglobin 20g/L, Hct of 50% , WBC count of 15,000 and elevated platelet count of 400,000.

Answer 18

Polycythemia vera

Question 19

Panmyelosis is a characteristic of which type of blood cancer?

Answer 19

Polycythemia vera

Question 20

48/F apparently asymptomatic. CBC : Platelet= 700 x 109/ L BM trephine: Normocellular marrow with megakaryocytic hyperplasia , megakaryocytes are morphilogically mature. Mutational analysis : JAK2(+). What is the diagnosis?

Answer 20

Essential thrombocytosis