West Nile Encephalitis

Question 1

What family is WNE part of

Answer 1

Flavaviridae

Question 2

What are the three conditions that can arise in WE

Answer 2

1. Asymptomatic infection
2. West Nile Fever
3. Neuroinvasive disease

Question 3

Describe the possible situations that can arise in neuroinvasive disease

Answer 3

1. Poliomylitis like condition
2. Meningoencephalitis
3. Encephalitis
4. Meningitis

Question 4

What is the breakdown of the complications arising from WNE

Answer 4

1. Most is asymptomatic
2. Some with west nile fever
3. Few with neuroinvasive disease

Question 5

Where does WNE enter and replicate

Answer 5

Langerhans dendritic cells then enters lymph nodes

Question 6

Does WNE result in a viremia

Answer 6

Yes

Question 7

Describe the Viremia

Answer 7

1. Virus to the reticuloendothelial system

2. Virus pass BBB to CNS where invades neurons

Question 8

Host species

Answer 8

Present in birds and mosquitos, transferred to humans/horse

Question 9

Control

Answer 9

No vaccine, just supportive.