Polyomaviridae Flashcards

1
Q

Viruses of polyomaviridae

A
  1. BK and JC viruses

2. SV40(simian polyomavirus) and murine polyomavirus

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2
Q

Structure of polyomaviruses

A

Smaller, less complex than papillomavirus

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3
Q

Replication locations of BK and JC

A

JC - respiratory tract, urinary tract, CNS

BK - respiratory tract, urinary tract

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4
Q

Patients susceptible to infection

A

immunocompromised patients

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5
Q

Pregnancy and BKJC viruses

A

viruses reactivated during pregnancy, no transmission to baby

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6
Q

Clinical presentation of a BK viral infection

A
  1. Ureteral stenosis in renal transplant patients

2. hemorrhagic cystitis in bone marrow transplant patients

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7
Q

Clinical presentation of a JC viral infection

A

Progressive multifocal leukoencephalopathy(PML)

  • virus infects oligodendrocyte cells, resulting in loss of white matter
  • changes to speech, vision, coordination, mental
  • paralysis and death
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8
Q

Prognosis of PML

A

1 to 4 months, death within 2 years

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9
Q

Pathogenesis of BK and JC

A
  • enter into respiratory tract, infect lymphocytes, and then kidney
  • BK establishes latent infection in kidney
  • JC infection in kidneys B cells, monocyte lineage cells
  • viral shedding in urine, severe urinary infection BK
  • viremia and CNS infection, JC
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10
Q

Control

A

none

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