Filoviridae

Question 1

Two virus of filoviridae that need to be known

Answer 1

Ebola and Marburg

Question 2

Nucleic acid of filoviridae virus

Answer 2

negative ; RNA

Question 3

Physical structure of filoviridae virus

Answer 3

Filamentous ; enveloped

Question 4

Overall damage by filoviridae virus

Answer 4

Microvasculature resulting in increased vascular permeability and cause severe or fatal hemorrhage

Question 5

Structure of nucleocapsid

Answer 5

Helical ; enclosed in an envelope containing one glycoprotein

Question 6

Location of replication

Answer 6

Cytoplasm

Question 7

Major complication of ebola or marbug

Answer 7

Hemorrhagic fever following incubation period 3-8 days

Question 8

Initial symptoms of filoviridae

Answer 8

• flu like symptoms like headache and myalgia

- nausea, vomiting, diarrhea

Question 9

Worsening symptoms of filoviridae

Answer 9

• Nausea, vomiting, pains, edema, headache, coma
• Mucosal hemorrhage, macropapular rash
• death due to metabolic disturbances, shock

Question 10

Ebola virus typical pathway through human being

Answer 10

1. Day 7-9; first symptoms of headache, fatigue, fever, muscle soreness
2. Day 10; sudden high fever, vomiting blood, passive
3. Day 11; bruising, brain damage, bleeding orifices
4. Day 12; loss of consciousness, seizures, BLEEDING, death

Question 11

Pathogenesis of filoviridae

Answer 11

-direct contact with body fluid, maybe skin/mucous

Question 12

Ebola characteristic

Answer 12

-destruction of the immune system

Question 13

Destruction of the endothelial cells leading to vascular injury due to

Answer 13

Ebola glycoprotein

Question 14

Pathway of the cells entering and causing damage

Answer 14

Review slide in the packet, NOW

Question 15

Control of filoviridae

Answer 15

None, no treatment