Coronavirus Flashcards
Nucleic acid of a coronavirus
positive SS RNA, non-segmented
Does coronavirus require polymerase
No, positive strand RNA acts like an mRNA
Capsid of a coronavirus
Helical capsid
Envelope of coronavirus
Derived from intracellular membranes and NOT from the plasma membrane.
Replication of coronavirus occurs
Within the cytoplasm
Protein that coronavirus binds to
-S protein bind to aminopeptidase N and sialic acid
Protein that is translated by for coronavirus
- translation of a RNA-dependent RNA polymerase
RNA dependent RNA polymerase encodes
- full length, (-) sense RNA template
2. six mRNAs for coronavirus proteins
Organelle the virion enter into
Rough endoplasmic reticulum
Virion released by cell by
exocytosis
Clinical presentation of Coronavirus
- Common cold; upper respiratory tract infection, self-limited
Incubation period for coronavirus
3 days
Symptoms of common cold
- sore throat, runny nose, congestion, sneezing, coughing
2. muscles aches, fatigue, headache
Cells coronavirus infects
epithelial cells of upper respiratory tract
Immune response to coronavirus
- infected cells; vacuolated, damaged cilia, syncytial
- production of inflammatory mediators, cause local swelling and inflammation
- stimulate sneezing, obstruct airway, raise temperature
- increased of interferon and antibodies
