Rabies Flashcards
1
Q
Family that Rabies is in
A
Rhabdovirus
2
Q
Main complication of Rabies
A
-infects CNS causing encephalopathy
3
Q
Capsid structure
A
Helical
4
Q
Is it enveloped
A
Yes
5
Q
Genome of Rabies
A
- negative
- single stranded
- RNA
6
Q
Replication occurs where in the cell
A
Cytoplasm
7
Q
Replication process for Rabies
A
- binds G-proteins on surface
- virus penetrates host cell via pinocytosis
- virus enters endosome, releasing into cytoplasm
- Viral polymerase transcribe genome into 5 mRNA and (+) RNA template
- Translation
- Replication
- Assembly
- Bud from plasma membrane
8
Q
The function of the 5 proteins N, P, M, G, L proteins
A
- NPL complex encapsulate (-) RNA to form RNP core
- M protein forms a capsule around RNP
- G protein processed in ER and Golgi
9
Q
Incubation period of rabies
A
20 to 90 days
10
Q
Description of the prodromal phase
A
- similar to flu: weakness, discomfort, fever, headache
- discomfort or itching sensation at the site of bite
11
Q
Description of neurological phase
A
- cerebral dysfunction, anxiety, confusion, agitation
- acute confusion, abnormal behavior, insomnia, hallucinations
- coma, hypotension, cardiac arthymia
12
Q
Problem when symptoms appear
A
Death is imminent
13
Q
Pathogenesis of rabies
A
- Virus enters animal bite
- virus replication in muscle at site of bite
- Virus infects PNS, moves by retrograde transport
- Virus replicates DRG, travels up spinal cord to brain
- Brain infected
- travels from brain to others tissues via nerves
14
Q
Where does the virus concentrate in
A
Salivary glands
15
Q
Most popular symptom is
A
Hydrophobia; virus invades and damages muscles involved with drinking and swallowing
