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MicroBio-Virus > Rabies > Flashcards

Rabies Flashcards

1
Q

Family that Rabies is in

A

Rhabdovirus

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2
Q

Main complication of Rabies

A

-infects CNS causing encephalopathy

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3
Q

Capsid structure

A

Helical

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4
Q

Is it enveloped

A

Yes

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5
Q

Genome of Rabies

A
  • negative
  • single stranded
  • RNA
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6
Q

Replication occurs where in the cell

A

Cytoplasm

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7
Q

Replication process for Rabies

A
  1. binds G-proteins on surface
  2. virus penetrates host cell via pinocytosis
  3. virus enters endosome, releasing into cytoplasm
  4. Viral polymerase transcribe genome into 5 mRNA and (+) RNA template
  5. Translation
  6. Replication
  7. Assembly
  8. Bud from plasma membrane
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8
Q

The function of the 5 proteins N, P, M, G, L proteins

A
  • NPL complex encapsulate (-) RNA to form RNP core
  • M protein forms a capsule around RNP
  • G protein processed in ER and Golgi
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9
Q

Incubation period of rabies

A

20 to 90 days

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10
Q

Description of the prodromal phase

A
  • similar to flu: weakness, discomfort, fever, headache

- discomfort or itching sensation at the site of bite

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11
Q

Description of neurological phase

A
  • cerebral dysfunction, anxiety, confusion, agitation
  • acute confusion, abnormal behavior, insomnia, hallucinations
  • coma, hypotension, cardiac arthymia
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12
Q

Problem when symptoms appear

A

Death is imminent

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13
Q

Pathogenesis of rabies

A
  1. Virus enters animal bite
  2. virus replication in muscle at site of bite
  3. Virus infects PNS, moves by retrograde transport
  4. Virus replicates DRG, travels up spinal cord to brain
  5. Brain infected
  6. travels from brain to others tissues via nerves
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14
Q

Where does the virus concentrate in

A

Salivary glands

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15
Q

Most popular symptom is

A

Hydrophobia; virus invades and damages muscles involved with drinking and swallowing

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16
Q

Common reservoir for rabies

A

-bats, foxes, raccons, skunk

17
Q

transmission of rabies

A

bite, scratch

18
Q

Diagnosis of rabies

A
  • histopathology
  • electron microscopy
  • direct fluorescent antibody test
  • immunohistochemistry
19
Q

Diagnosis of rabies

A
  1. mononuclear infiltration
  2. perivascular cuffing of lymphocytes or polymorphonuclear cells
  3. lymphocytic foci
  4. babes nodules consisting of glial cells
  5. negri bodies
20
Q

Control of rabies

A
  • specific immunoglobin immunization

- vaccine started and 3 doses

MicroBio-Virus (29 decks)

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