Hepatitis D virus Flashcards
1
Q
Overall strength of hepatitis D
A
- highly defective virus
- produce infective virions if co-infecting helping virus present
2
Q
Genome of hepatitis D virus
A
- negative
- single stranded
- RNA
3
Q
A characteristic of hepatitis D virus genome
A
RNA covalently closed circle
4
Q
Protein required by hepatitis D for replication
A
HBsAg
5
Q
Protein encoded by RNA of hepatitis D
A
delta antigen: complexes with RNA
6
Q
Co-infection can occur with
A
HBV
7
Q
Symptoms of co-infections of HBV and HDV
A
- severe acute disease
- liver failure
- complete recovery - low risk of chronic infection
8
Q
Symptoms of super-infections with positive HBsAG
A
- fulimant hepatitis
- chronic HDV infection(cirrhosis and liver cancer)
9
Q
Control of hepatitis D
A
- prevention of infection with HBV
- alphaIFN + lamivudine for chronic infection
