Adenovirus Flashcards
1
Q
Structure composition of core protein hemagglutinin
A
Penton base + fiber + knob domain
2
Q
Genome of adenovirus
A
- linear
- double stranded
- DNA
3
Q
Capsid of adenovirus
A
Icosahedral
4
Q
Is it enveloped?
A
No
5
Q
Replication process of adenovirus
A
- Binds to CAR receptor
- Alphav integrins binds to penton base on adenovirus
- internalization of adenovirus via endocytosis
6
Q
Transcription, replication, and assembly takes place
A
Nucleus of infected cell
7
Q
Two phases of transcription, and divided by?
A
Early and late transcription, divided by DNA replication
8
Q
Polymerase used for mRNA synthesis?
A
host cell RNA polymerase
9
Q
Early mRNAs transcribed from which regions
A
E1, E2, E3, E4
10
Q
Intermediate early genes?
A
E1A and E1B
11
Q
Genes transcribed following E1A and E1B
A
E2, E3, E4
12
Q
Early genes are involved in
A
- DNA synthesis
- Alter expression of host cell genes
- Transcription of late genes(L1-L5)
13
Q
Functions of early mRNAs
A
- Block CTL response
- modulate cell cycle
- block apoptosis
- shut down mRNA host transport
- DNA replication of progeny DNA
14
Q
Functions of late mRNAs
A
- Virion assembly
2. Cell lysis
15
Q
Clinical presentation of adenovirus
A
- respiratory tract disease
- ocular disease
- acute hemorrhagic cystitis
- gastroenteritis
- infections in immunosuppressed
