Rubella Flashcards
1
Q
What family of virus is this deck about?
A
Togaviridae
2
Q
What two viruses are included in the Togaviridae family
A
- Rubella(German Measles)
2. Alphavirus
3
Q
Genome of Rubella
A
- positive
- single stranded
- RNA
- 1segment
4
Q
Capsid shape of Rubella
A
Icosahedral
5
Q
Is it enveloped?
A
Yes
6
Q
Inactivated by what?
A
- chemical agents
- UV
- Low pH
- heat
7
Q
Replication process for Rubella
A
-positive RNA so immediately binds to ribosome
8
Q
How is the mRNA of rubella translated
A
- 2/3 genome is translated into one polypeptide protein
- polypeptide protein cleaved into 4
- protease and RNA dependent RNA polymerase
- 1/3 genome into capsid, envelope
9
Q
Risk to pregnant woman
A
- pregnant women: fetal death or congenital defects
- congenital rubella syndrome
10
Q
Transmission of Rubella
A
-person to person via droplets from respiratory tract
11
Q
Incubation period of Rubella
A
14 to 21 days
12
Q
Symptoms of Rubella in children
A
- rash, low fever, mild conjunctivitis
- rash on face, neck then body for 1-3 days
- swollen lymph nodes behind ears and in neck
13
Q
Additional symptoms of Rubella typically in adults
A
- arthritis
- painful joints
- 3 to 10 days
14
Q
Description of congenital rubella syndrome
A
- hearing impairments
- eye and heart defects
- autism, diabetes mellitus, thyroid dysfunction
15
Q
Most common complications from congenital rubella syndrome
A
- hearing loss
- congenital heart disease including PDA
- ocular abnormalities ie cataracts
- Microencephaly
