Week 8: Disorders of Ca2+ Homeostasis Flashcards

1
Q

Principles of Ca2+ physiology

A
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2
Q

What is extracellular Ca2+ needed for?

A

is required to maintain normal biological function of nervous system and blood coagulation

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3
Q

What is intracellular Ca2+ needed for?

A
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4
Q

How does Ca2+ circulate

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5
Q

Describe the mechanisms of normal Ca2+ flux

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6
Q

Describe hormone and Ca2+ homeostasis

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7
Q

Describe Calcitonin

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8
Q

Describe PTH

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9
Q

Parathyroid glands

A
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10
Q

Normal parathyroid function requires how many glands

A

at least 2 of the 4 functioning glands

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11
Q

Renal parathyroid hormone effects

A
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12
Q

Bone parathyroid hormone effects

A
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13
Q

Gut parathyroid hormone effects

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14
Q

Interpreting PTH & Ca2+ lab tests

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15
Q

Describe Vitamin D

A
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16
Q

Describe Vitamin D metabolism

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17
Q

Describe Vitamin D metabolism

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18
Q

Hypocalcemia

A
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19
Q

DDx of hypocalcemia

A
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20
Q

Primary hypoparathyroidism

A
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21
Q

Pseudohypoparathyroidism

A
22
Q

Vitamin D deficiency

A
23
Q

Vitamin D dependent Rickets Type 1

A
24
Q

Vitamin D dependent Rickets Type 2

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25
Q

Acute Tx of hypocalcemia

A
26
Q

Tx of chronic hypocalcemia

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27
Q

DDx of hypercalcemia

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28
Q

Complications of hypercalcemia

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29
Q

Primary hyperparathyroidism

A
30
Q

Clinical features of HPT

A
31
Q

Primary Hyper PTH clinical features

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32
Q

Hyper PTH Work-up

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33
Q

Lab abnormalities in HPT

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34
Q

Indications for surgery in primary HPT

A
35
Q

Other considerations for surgery for HPT

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36
Q

Pre-operative imaging

A
37
Q

Parathyroid adenomas imaging

A

Technitium99-Sestamibi

38
Q

Natural Hx of Asymptomatic HPT

A
39
Q

Medical management primary HPT

A
40
Q

Familial Syndromes of HPT

A
41
Q

MEN syndromes

A
42
Q

Granulomatous Disease

A
43
Q

Hypercalcemia of malignancy

A
44
Q

Medications for hypercalcemia of malignancy

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45
Q

Familial benign hypercalcemia

A
46
Q

Creatinine Clearance ratio

A
47
Q

Secondary PTH: Renal failure

A
48
Q

Secondary hyper-PTH

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49
Q

Tertiary HPT

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50
Q

Other causes of hypercalcemia

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51
Q

Sally brooks

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52
Q

Disorders of Ca2+ homeostasis Conclusions

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