Week 3: Celiac Disease Flashcards by Jay Sandoval

Q

What is celiac disease?

A

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Q

How is the autoimmune response triggered in celiac disease

A

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Q

HLA types common in Celiac disease

A

HLA DQ2

HLA DQ8

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Q

Different serological types of celiac disease

A

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Q

Question

A

D. Submucosa

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Q

Question

A

B. Lamina Propria

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Q

What is the main difference between small intestinal mucosa and colonic mucosa?

A

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Q

Differences in function of small intestine and colon

A

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Q

Describe histologic features of small intestine

A

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Q

Describe histologic features of the large intestine

A

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Q

Question

A

D. Goblet cell

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Q

Villi compared to crypts

A

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Q

Celiac Disease Diagnostic criteria

A

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Q

Who diagnoses Celiac disease

A

E.

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Q

Pathologic histologic features of celiac disease

A

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Q

Small intestinal CD3 stain

A

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Q

Question

A

A. the one on the left

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Q

Histologic features of celiac disease

A

Q

What is the preferred biopsy location for celiac disease

A

Q

Describe histological features of 1st and 2nd portions of duodenum

A

1st is more sensitive for celiac has a lot of Brunners glands
2nd part is more specific for celiac

Q

Mucosal damage and symptomology or serology

A

Q

MARSH Classifications

A

Q

Describe these features

A

Q

Compare celiac histology to normal small intestine

A

Q

Compare celiac histology to colon

A

Q

Question

A

Q

Anti-tTG levels can be elevated in?

A

Q

Other serological tests for celiac disease

A

Q

HLA testing benefits for celiac disease

A

Q

Assume a different scenario

A

No, lack of blah blah

Q

Are IELs and villous blunting pathognomonic of celiac

A

Q

Differentials of celiac disease

A

Q

How common are increased IELs in duodenal biopsies?

A

Q

What is the best initial test for celiac disease?

A

Anti-tTG test

Q

Summary of celiac disease

A

Q

Algorithm of celiac disease testing

A

Q

Question

A

Looks normal

B. Villi are the right height

Q

Question

A

too many lymphocytes in the villus tip

Q

CD3 stain

A

way too many lymphocytes at the villus tips

Q

Question

Is this celiac disease?

A

C Maybe poster child for gluten diet restriction

Q

Describe

A

stomach

antral mucosa 2x

lymphoplasmacytic infiltrate along superficial aspect of antral mucosa

Q

Diagnosis

A

H. pylori

Q

Celiac disease complications

A

Q

What is refractory celiac disease?

A