Week 3: Small intestine motility Flashcards
Main functions of the small intestine

What are the different types of contraction patterns in the small intestine?
- Segmentation
- Peristalsis
- Migrating motor complexes
Describe segmentation contraction pattern
- Major contractile activity of the small intestine
- mixing function
Describe the peristalsis contraction pattern of the small intestine
generally short-range propulsion, 15-20/hr
Describe the Migrating Motor Complexes contraction pattern of the small intestine
Clearance at regular intervals during fasting state
What is the most common type of contraction pattern in the small intestine?
Segmentation
Function of the segmentation contraction pattern in the small intestine
effectively mixes chyme with digestive secretions “chopping” chyme as much as 8-12 times/minute
Brings fresh chyme into contact with the mucosal surface
Describe the physiology of the segmentation contraction pattern


What is the function of the peristalsis contraction pattern of the small intestine
contributes to propagation along the small intestine
Describe the physiology of the peristalsis contraction pattern of the small intestine

Describe the Migrating motor complex

How are the small intestine contractile patterns regulated?

Describe pacemaker activity in the small intestine
- electrical slow waves driven by interstitial cells of Cajal -5 sec intervals
- neuronal and hormonal activity act on top of slow waves to determine contractility

Electrical slow waves

Electrical slow waves

Electrical slow waves

Electrical slow waves

Describe the hormonal regulation of motility

Describe releasers of Gastrointestinal hormones

Describe the actions of GI hormones

Actions of GI hormones

Actions of GI hormones

Question

Question

Describe GI hormone regulation of motility in response to a meal

Describe GI hormonal regulation in the fasting state

Describe the function of enteric neuronal reflexes

Describe the physiology of parasympathetic enhancement

Describe the physiology of parasympathetic enhancement of the vagus nerve

Describe the physiology of parasympathetic enhancement of the enteric ganglion
how does parasympathetic enhancement regulate motility reflexes?

What neurotransmitter is used for parasympathetic enhancement

Summary of parasympathetic enhancement

Describe the origins of sympathetic inhibition of

Describe the physiology of sympathetic inhibition of

Prevertebral ganglia sympathetic inhibition

Prevertebral ganglia sympathetic inhibition

What is the neurotransmitter of sympathetic inhibition

How does sympathetic inhibition affect GI motility

sympathetic inhibition histology

Primary targets of sympathetic inhibition

Presynaptic adrenoreceptors sympathetic inhibition

Presynaptic adrenoreceptors neurotransmitter

Effect of presynaptic sympathetic inhibition

Sympathetic inhibition

Examples of abnormal small intestinal mobility

Describe post-operative ileus

Summary of small intestinal motility
