Week 8 - CNS Antidepressants Flashcards
What are the degrees of depression?
Mild = slight deviation from normalility Severe = psychosis with hallucinations and delusions
Describe the emotional component of depression.
- Misery, apathy, pessimism
- Low self-esteem, indecisiveness, loss of motivation
Describe the biological component of depression
- Retarded though and action
- Loss of libido, sleep disturbances, loss of apetite
Describe Unipolar depression.
-mood swings always in same direction
Describe Bipolar affective dissorder
- depression and mania
- Manic symptoms opposite to depression
- Enthusiasm, exuberance, self confidence
- Irritability, impatience, aggression
Describe the Monoamine theory of depression?
- Deficit in Monoamine neurotransmitters, especially 5-HT and NA
- Excessive monoamine = mania
- Treatment based on restoring balance
Describe Bipolar affective dissorder
- depression and mania
- Manic symptoms opposite to depression
- Enthusiasm, exuberance, self confidence
- Irritability, impatience, aggression
Describe the Monoamine theory of depression?
- Deficit in Monoamine neurotransmitters, especially 5-HT and NA
- Increased monoamine = mania
What are the 4 classes of drugs usedto treat depression?
- Tricyclic antidepressants
- 5-HT uptake inhibitors
- Monoamine oxidase inhibitors (MAOI)
- Atypical antidepressants
What are the actions, effects and examples of Tricyclic Antidepressants?
-Inhibit reuptake of monoamines (5-HT/NA)
- Enhance the effects of monoamines
Eg. amitriptyline
What are the actions, effects and examples of 5-HT uptake inhibitors?
-Inhibit reuptake of 5-HT
- enhance the effect
Eg. Fluoxetine (Prozac)
What are the advantages and uses of 5-HT uptake inhibitors?
- Less side effects than TCA
- Used for anxiety and OCD
What are the actions, effects and examples of Monoamine oxidase inhibitors?
-Inhibit the enzyme of catecholamines
-controls levels of NA and 5-HT in nerve terminal
-increase levels of monoamines
Eg. Phenelzine
