Week 8 - CNS Flashcards
1
Q
What are the 4 types of CNS drugs?
A
- Anxiolytics and sedatives
- Antidepressants
- Antipsychotics
- Anaesthetics
2
Q
What are the major CNS neurotransmitters?
A
- Glutamate (EAA)
- GABA (IAA)
- Glycine (IAA)
- ACh
- 5-HT
- Dopamine
- NA
3
Q
What is required for NMDA receptors to activate? Giving an example of a channel blocker.
A
- Both glycine and glutamine are required for activation
- Ketamine blocks NMDA channels
4
Q
What are the receptor, action, and agonists for GABA a receptor?
A
- Cl channel receptor
- Reduce membrane excitability
- Benzodiazapines (anxiolytics)
- Barbituates (sedatives)
5
Q
What are the receptor, action, and agonists for GABA b receptor?
A
- GPCR (inhibit cAMP)
- inhibit Ca channel opening and K conductance
- Baclofen as an anti-spactic in para/quadraplegia
6
Q
What is the action and clinical relevance of Excitory Amino-Acids?
A
EAA and their receptors stimulate generation on nerve impulse
- over activation = seizures
7
Q
What is the action and clinical relevance of Inhibitory Amino-Acids?
A
IAA and their receptors suppress the generation on nerve impulses
- over activation = CNS depression
