Furosemide Poster

Question 1

What is Furosemides mechanism of action?

Answer 1

• Inhibits Na/K/Cl symporter in the thick ascending limb

Question 2

What is the effects of Furosemide?

Answer 2

• increases excretion of electrolytes
• increases water excretion
• prevents absorption of Na+ and Cl-

Question 3

What are the clinical uses of Furosemide?

Answer 3

• pulmonary oedema
• congestive cardiac failure (CCF)
• liver cirrhosis complicated by ascites
• nephrotic syndrome
• renal failure

Question 4

What is the ADME of Furosemide?

Answer 4

Ad= Orally, IM, IV
Ab= GIT (PO)
D= Bind 99% to Plasma Proteins
M= Undergo Glucuronidation in the Liver
E= Urinary and Faecal

Question 5

What are the side-effects of Furosemide?

Answer 5

hypokalaemia
hypocalcaemia
hyponatremia
hyperuricaemia